MAP3K1 mitogen-activated protein kinase kinase kinase 1 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: MAP3K1provided by VGNC
Official Full Name: mitogen-activated protein kinase kinase kinase 1provided by VGNC
Primary source: VGNC:VGNC:31188
See related: BGD:BT19218; Ensembl:ENSBTAG00000013790
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	20	NC_037347.1 (22340163..22417428, complement)

Chromosome 20 - NC_037347.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

REN28005 (e-PCR)
- UniSTS:352805

REN28301 (e-PCR)
- UniSTS:353101

REN28305 (e-PCR)
- UniSTS:353105

ECD05748 (e-PCR)
- UniSTS:286810

REN28358 (e-PCR)
- UniSTS:353158

REN28361 (e-PCR)
- UniSTS:353161

stSG625152 (e-PCR)
- UniSTS:456344

stSG625159 (e-PCR)
- UniSTS:456351

ECD09442 (e-PCR)
- UniSTS:290485

ECD08178 (e-PCR)
- UniSTS:289226

ECD13328 (e-PCR)
- UniSTS:294358

REN27681 (e-PCR)
- UniSTS:352481

ECD10515 (e-PCR)
- UniSTS:291554

CC472921 (e-PCR)
- UniSTS:476648

MAP3K1_3196 (e-PCR)
- UniSTS:462331

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase 1

NP_001192835.1

EC 2.7.11.25

XP_005221555.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205906.1 → NP_001192835.1 mitogen-activated protein kinase kinase kinase 1

See identical proteins and their annotated locations for NP_001192835.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000020

UniProtKB/TrEMBL

E1B847

Related

ENSBTAP00000018325.4, ENSBTAT00000018325.5

Conserved Domains (2) summary

smart00220
Location:1238 → 1503

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06630
Location:1237 → 1504

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

Range

22340163..22417428 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005221498.5 → XP_005221555.1 mitogen-activated protein kinase kinase kinase 1 isoform X1

Related

ENSBTAP00000096807.1, ENSBTAT00000097816.1

Conserved Domains (2) summary

smart00220
Location:1076 → 1341

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06630
Location:1075 → 1342

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1