PLD2 phospholipase D2 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: PLD2provided by VGNC
Official Full Name: phospholipase D2provided by VGNC
Primary source: VGNC:VGNC:32996
See related: Ensembl:ENSBTAG00000013392
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (26543146..26556149, complement)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming.
Title: Phospholipase D2 mediates acute aldosterone secretion in response to angiotensin II in adrenal glomerulosa cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phospholipase D activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell motility	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidic acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phospholipase D2

Names: PLD 2; choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2

NP_001069295.1

EC 3.1.4.4

XP_059734043.1

EC 3.1.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001075827.1 → NP_001069295.1 phospholipase D2

See identical proteins and their annotated locations for NP_001069295.1

Status: PROVISIONAL

Source sequence(s)

BC123547

UniProtKB/Swiss-Prot

Q08DV7, Q0V8L6

UniProtKB/TrEMBL

F1MYP2

Related

ENSBTAP00000072886.1, ENSBTAT00000080368.2

Conserved Domains (5) summary

cd09845
Location:614 → 795

PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2

PLN02866
Location:67 → 918

PLN02866; phospholipase D

cd01254
Location:180 → 309

PH_PLD; Phospholipase D pleckstrin homology (PH) domain

cl02563
Location:62 → 192

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl15239
Location:335 → 475

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins