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RAF1 Raf-1 proto-oncogene, serine/threonine kinase [ Bos taurus (cattle) ]

Gene ID: 521196, updated on 4-Apr-2024

Summary

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Gene symbol
RAF1
Gene description
Raf-1 proto-oncogene, serine/threonine kinase
See related
Ensembl:ENSBTAG00000045748
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
C-RAF
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (56467496..56543344)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104975605 Neighboring gene transmembrane protein 40 Neighboring gene makorin ring finger protein 2 Neighboring gene PPARG-TSEN2 Neighboring gene MKRN2 opposite strand Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene tRNA splicing endonuclease subunit 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway. Li J, et al. Am J Physiol Cell Physiol, 2007 Jun. PMID 17329403
  2. Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21. Threadgill DS, et al. Genomics, 1991 Dec. PMID 1783381
  3. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
  4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data suggest that G alpha(i3), Shc, Grb2, Ras, and Raf-1 link Src to activation of MAPK and to the AT(2)-dependent increase in eNOS expression in PAECs
    Title: Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC165882

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAF proto-oncogene serine/threonine-protein kinase
Names
proto-oncogene c-RAF
NP_001095975.1
XP_024838494.1
XP_024838495.1
XP_024838496.1
XP_024838497.1
XP_059735658.1
XP_059735659.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102505.1 → NP_001095975.1  RAF proto-oncogene serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001095975.1

    Status: PROVISIONAL

    Source sequence(s)
    BC151319
    UniProtKB/Swiss-Prot
    A7E3S4
    Related
    ENSBTAP00000005930.6, ENSBTAT00000005930.6
    Conserved Domains (3) summary
    cd01816
    Location:57 → 131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139 → 187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    56467496..56543344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024982726.2 → XP_024838494.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    cd01816
    Location:57 → 131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139 → 187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_024982728.2 → XP_024838496.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    A7E3S4, A7YY51
    Conserved Domains (3) summary
    cd01816
    Location:57 → 131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139 → 187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. XM_024982727.2 → XP_024838495.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    A7E3S4, A7YY51
    Conserved Domains (3) summary
    cd01816
    Location:57 → 131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139 → 187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. XM_059879676.1 → XP_059735659.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

  5. XM_024982729.2 → XP_024838497.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    A7E3S4, A7YY51
    Related
    ENSBTAP00000048678.3, ENSBTAT00000054270.3
    Conserved Domains (3) summary
    cd01816
    Location:57 → 131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139 → 187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  6. XM_059879675.1 → XP_059735658.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7E3S4.1 GenPept UniProtKB/Swiss-Prot:A7E3S4

Gene LinkOut

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