MSRB1 methionine sulfoxide reductase B1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MSRB1provided by HGNC
Official Full Name: methionine sulfoxide reductase B1provided by HGNC
Primary source: HGNC:HGNC:14133
See related: Ensembl:ENSG00000198736 MIM:606216; AllianceGenome:HGNC:14133
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SELR; SELX; SepR; SEPX1; HSPC270; SELENOR; SELENOX
Summary: The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in kidney (RPKM 37.2), liver (RPKM 35.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (1938229..1943199, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (1958200..1963171, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (1988230..1993200, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The selenoprotein methionine sulfoxide reductase B1 (MSRB1).
Title: The selenoprotein methionine sulfoxide reductase B1 (MSRB1).
In vivo, MsrB1 shRNAi can inhibit lung metastasis in metastasis model. In conclusion, MsrB1 regulates proliferation and invasion of u2os cells by affecting MAPK pathway and EMT, and MsrB1 gene may be a novel therapeutic target against tumors.
Title: Methionine sulfoxide reductase B1 regulates proliferation and invasion by affecting mitogen-activated protein kinase pathway and epithelial-mesenchymal transition in u2os cells.
FRET and co-IP assays demonstrated that Clu interacted with beta-amyloid peptide, a pathological protein of AD, which suggested a potential effect of SelR and Abeta with the aid of Clu. The interaction between SelR and Clu provides a novel avenue for further study on the mechanism of SelR in AD prevention.
Title: Direct Interaction of Selenoprotein R with Clusterin and Its Possible Role in Alzheimer's Disease.
MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption.
Title: Effect of methionine sulfoxide reductase B1 (SelR) gene silencing on peroxynitrite-induced F-actin disruption in human lens epithelial cells.
findings suggested that SelX played important roles in protecting LO2 cells against oxidative damage and reducing H2O2-induced apoptosis in liver cells.
Title: Selenoprotein X Gene Knockdown Aggravated H2O2-Induced Apoptosis in Liver LO2 Cells.
Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress
Title: Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.
Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress.
Title: Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.
MsrB1 plays important roles in protecting HLE cell mitochondria against oxidative damage and inhibits oxidative stress-induced apoptosis in diabetic cataracts by scavenging ROS.
Title: Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced apoptosis of human lens epithelial cells.
The results demonstrate that in human lens epithelial cells MsrB1 may play important roles in regulating redox balance and mitigating endoplasmic reticulum stress.
Title: Involvement of MsrB1 in the regulation of redox balance and inhibition of peroxynitrite-induced apoptosis in human lens epithelial cells.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80593 (e-PCR)
- UniSTS:85866

RH93499 (e-PCR)
- UniSTS:87737

SEPX1_9756 (e-PCR)
- UniSTS:468682

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables L-methionine-(R)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptide-methionine (R)-S-oxide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-methionine (R)-S-oxide reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide-methionine (R)-S-oxide reductase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein repair	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein repair	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cellular_component	ND No biological Data available more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: methionine-R-sulfoxide reductase B1

Names: selenoprotein R; selenoprotein X, 1

NP_001369193.1

EC 1.8.4.12

EC 1.8.4.14

NP_001369194.1

EC 1.8.4.12

EC 1.8.4.14

NP_057416.1

EC 1.8.4.12

EC 1.8.4.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001382264.1 → NP_001369193.1 methionine-R-sulfoxide reductase B1 isoform 2

Status: REVIEWED

Source sequence(s)

AC005363

Conserved Domains (1) summary

cl15841
Location:7 → 59

SelR; SelR domain
NM_001382265.1 → NP_001369194.1 methionine-R-sulfoxide reductase B1 isoform 3

Status: REVIEWED

Source sequence(s)

AC005363

Conserved Domains (1) summary

cl15841
Location:7 → 61

SelR; SelR domain
NM_016332.4 → NP_057416.1 methionine-R-sulfoxide reductase B1 isoform 1

See identical proteins and their annotated locations for NP_057416.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC005363

Consensus CDS

CCDS42100.1

UniProtKB/Swiss-Prot

Q96RX6, Q9BTV2, Q9NZV6, Q9P0B1

Related

ENSP00000355084.3, ENST00000361871.8

Conserved Domains (1) summary

cl15841
Location:7 → 105

SelR; SelR domain