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STAT4 signal transducer and activator of transcription 4 [ Bos taurus (cattle) ]

Gene ID: 515988, updated on 11-Apr-2024

Summary

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Official Symbol
STAT4provided by VGNC
Official Full Name
signal transducer and activator of transcription 4provided by VGNC
Primary source
VGNC:VGNC:106954
See related
BGD:BT28700; Ensembl:ENSBTAG00000046699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (79568834..79705358, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene glutaminase Neighboring gene uncharacterized LOC104971266 Neighboring gene signal transducer and activator of transcription 1 Neighboring gene myosin IB Neighboring gene uncharacterized LOC132343173 Neighboring gene nucleic acid binding protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An SduI polymorphism at intron 20 of the Chinese Holstein cow STAT4 gene and its effect on milk performance traits. Song XM, et al. Genet Mol Res, 2013 May 13. PMID 23765966
  2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that the 2 single nucleotide polymorphisms of STAT4 could be used as genetic markers for milk performance traits in Chinese Holstein cows.
    Title: An SduI polymorphism at intron 20 of the Chinese Holstein cow STAT4 gene and its effect on milk performance traits.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC157175

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083692.2 → NP_001077161.2  signal transducer and activator of transcription 4

    See identical proteins and their annotated locations for NP_001077161.2

    Status: VALIDATED

    Source sequence(s)
    CB466601, CK775168, DV882279, EH161302, NKLS02000002
    UniProtKB/TrEMBL
    F1N0R2
    Related
    ENSBTAP00000030561.5, ENSBTAT00000030584.5
    Conserved Domains (4) summary
    cd10375
    Location:553 → 700
    SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140 → 314
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:316 → 562
    STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    79568834..79705358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025001441.2 → XP_024857209.1  signal transducer and activator of transcription 4 isoform X1

    UniProtKB/TrEMBL
    F1N0R2
    Conserved Domains (4) summary
    cd10375
    Location:553 → 700
    SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140 → 314
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:316 → 562
    STAT_bind; STAT protein, DNA binding domain

  2. XM_059874387.1 → XP_059730370.1  signal transducer and activator of transcription 4 isoform X1

    UniProtKB/TrEMBL
    F1N0R2

  3. XM_025001444.2 → XP_024857212.1  signal transducer and activator of transcription 4 isoform X1

    UniProtKB/TrEMBL
    F1N0R2
    Conserved Domains (4) summary
    cd10375
    Location:553 → 700
    SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140 → 314
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:316 → 562
    STAT_bind; STAT protein, DNA binding domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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