PLCB3 phospholipase C beta 3 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: PLCB3provided by VGNC
Official Full Name: phospholipase C beta 3provided by VGNC
Primary source: VGNC:VGNC:32982
See related: Ensembl:ENSBTAG00000056084
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	29	NC_037356.1 (42555433..42572810)

Chromosome 29 - NC_037356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

investigation of physiological involvement of PLCbeta3 signaling in ovulatory-size follicles: identification of PLCbeta3 as a mediator of LH-induced differentiation responses of granulosa cells; up-regulation of PLCbeta3 during oogenesis/ovulation
Title: Phospholipase Cβ3 mediates LH-induced granulosa cell differentiation.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

NP_001179352.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001192423.4 → NP_001179352.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

See identical proteins and their annotated locations for NP_001179352.1

Status: PROVISIONAL

Source sequence(s)

BE809044, NKLS02000029

UniProtKB/TrEMBL

E1BHX7

Related

ENSBTAT00000097714.1

Conserved Domains (7) summary

cd00275
Location:728 → 843

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08625
Location:316 → 693

PI-PLCc_beta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta3

cd13361
Location:22 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam08703
Location:1030 → 1202

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:225 → 315

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cd16269
Location:1157 → 1168

GBP_C; coiled coil [structural motif]

cl20817
Location:1028 → 1188

GBP_C; Guanylate-binding protein, C-terminal domain