U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PLD1 phospholipase D1 [ Bos taurus (cattle) ]

Gene ID: 514554, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
PLD1provided by VGNC
Official Full Name
phospholipase D1provided by VGNC
Primary source
VGNC:VGNC:50244
See related
BGD:BT12890; Ensembl:ENSBTAG00000017490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PLD1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (95687380..95963604)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345697 Neighboring gene uncharacterized LOC132345694 Neighboring gene uncharacterized LOC132345699 Neighboring gene transmembrane protein 212 Neighboring gene small ribosomal subunit protein eS6-like Neighboring gene Krueppel-like factor 3 pseudogene Neighboring gene uncharacterized LOC132345702 Neighboring gene uncharacterized LOC101905533 Neighboring gene TRAF2 and NCK interacting kinase Neighboring gene thymosin beta-4-like

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells. Qin H, et al. J Endocrinol, 2009 Jul. PMID 19372190, Free PMC Article
  2. A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. Olala LO, et al. Mol Cell Endocrinol, 2013 Feb 5. PMID 23178798, Free PMC Article
  3. Pegasoferae, an unexpected mammalian clade revealed by tracking ancient retroposon insertions. Nishihara H, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16785431, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that PKD is downstream of PLD and suggest that PKD is one of the mechanisms through which PLD promotes aldosterone production in response to AngII in adrenal glomerulosa cells.
    Title: A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.
  2. Ca(2+) entry only through certain Ca(2+) influx pathways is linked to PLD activation.
    Title: The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC166213

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of microvillus assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
phospholipase D1
Names
phospholipase D1, phosphatidylcholine-specific
NP_001095471.1
XP_005201734.1
XP_005201735.1
XP_005201736.1
XP_005201738.1
XP_005201739.1
XP_010799678.1
XP_015327978.1
XP_024841831.1
XP_059738089.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102001.1 → NP_001095471.1  phospholipase D1

    See identical proteins and their annotated locations for NP_001095471.1

    Status: PROVISIONAL

    Source sequence(s)
    BC150123
    UniProtKB/TrEMBL
    A0A3Q1LL74, A6QR57, F1MZI9
    Related
    ENSBTAP00000042452.4, ENSBTAT00000045023.5
    Conserved Domains (5) summary
    cd07296
    Location:78 → 210
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09844
    Location:714 → 895
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:82 → 1019
    PLN02866; phospholipase D
    cd01254
    Location:198 → 327
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl15239
    Location:353 → 501
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    95687380..95963604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015472492.3 → XP_015327978.1  phospholipase D1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LL74
    Conserved Domains (5) summary
    cd07296
    Location:78 → 210
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:353 → 503
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:754 → 935
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:82 → 1059
    PLN02866; phospholipase D
    cd01254
    Location:198 → 327
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

  2. XM_005201681.5 → XP_005201738.1  phospholipase D1 isoform X1

    See identical proteins and their annotated locations for XP_005201738.1

    UniProtKB/TrEMBL
    A0A3Q1LL74
    Conserved Domains (5) summary
    cd07296
    Location:78 → 210
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:353 → 503
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:754 → 935
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:82 → 1059
    PLN02866; phospholipase D
    cd01254
    Location:198 → 327
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

  3. XM_005201682.5 → XP_005201739.1  phospholipase D1 isoform X3

    See identical proteins and their annotated locations for XP_005201739.1

    UniProtKB/TrEMBL
    A0A3Q1LL74
    Conserved Domains (5) summary
    cd07296
    Location:78 → 210
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:353 → 503
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:716 → 897
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:82 → 1021
    PLN02866; phospholipase D
    cd01254
    Location:198 → 327
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

  4. XM_059882106.1 → XP_059738089.1  phospholipase D1 isoform X1

  5. XM_024986063.2 → XP_024841831.1  phospholipase D1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1LL74, A0A3Q1LM46
    Related
    ENSBTAP00000069972.2, ENSBTAT00000068010.2
    Conserved Domains (1) summary
    cl26365
    Location:82 → 1002
    PLN03008; Phospholipase D delta

  6. XM_005201677.5 → XP_005201734.1  phospholipase D1 isoform X1

    See identical proteins and their annotated locations for XP_005201734.1

    UniProtKB/TrEMBL
    A0A3Q1LL74
    Related
    ENSBTAP00000060513.2, ENSBTAT00000076794.2
    Conserved Domains (5) summary
    cd07296
    Location:78 → 210
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:353 → 503
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:754 → 935
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:82 → 1059
    PLN02866; phospholipase D
    cd01254
    Location:198 → 327
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

  7. XM_005201679.5 → XP_005201736.1  phospholipase D1 isoform X3

    See identical proteins and their annotated locations for XP_005201736.1

    UniProtKB/TrEMBL
    A0A3Q1LL74
    Conserved Domains (5) summary
    cd07296
    Location:78 → 210
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:353 → 503
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:716 → 897
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:82 → 1021
    PLN02866; phospholipase D
    cd01254
    Location:198 → 327
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

  8. XM_010801376.4 → XP_010799678.1  phospholipase D1 isoform X1

    See identical proteins and their annotated locations for XP_010799678.1

    UniProtKB/TrEMBL
    A0A3Q1LL74
    Conserved Domains (5) summary
    cd07296
    Location:78 → 210
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:353 → 503
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:754 → 935
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:82 → 1059
    PLN02866; phospholipase D
    cd01254
    Location:198 → 327
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

  9. XM_005201678.3 → XP_005201735.1  phospholipase D1 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LL74
    Conserved Domains (5) summary
    cd07296
    Location:42 → 174
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:317 → 467
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:718 → 899
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:46 → 1023
    PLN02866; phospholipase D
    cd01254
    Location:162 → 291
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

RNA

  1. XR_009493069.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.