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PDE4D phosphodiesterase 4D [ Homo sapiens (human) ]

Gene ID: 5144, updated on 16-Apr-2024

Summary

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Official Symbol
PDE4Dprovided by HGNC
Official Full Name
phosphodiesterase 4Dprovided by HGNC
Primary source
HGNC:HGNC:8783
See related
Ensembl:ENSG00000113448 MIM:600129; AllianceGenome:HGNC:8783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2
Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Expression
Broad expression in bone marrow (RPKM 7.8), lung (RPKM 3.1) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
5q11.2-q12.1
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (58969038..60522128, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (59787596..61345916, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (58264865..59792113, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:57839100-57840299 Neighboring gene NANOG hESC enhancer GRCh37_chr5:57858257-57858782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16034 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86582 Neighboring gene long intergenic non-protein coding RNA 2108 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86593 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:58013208-58014189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16035 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86681 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:58186496-58187695 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58232852-58233452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58233453-58234051 Neighboring gene Sharpr-MPRA regulatory region 1719 Neighboring gene ribosomal protein L5 pseudogene 15 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:58276599-58277183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58298739-58299634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16036 Neighboring gene MPRA-validated peak5258 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58422602-58423512 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58423513-58424422 Neighboring gene MPRA-validated peak5260 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr5:58454460-58454961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16037 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:58624407-58625606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:58690566-58691066 Neighboring gene uncharacterized LOC107986347 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:58858724-58859374 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:59004928-59005660 Neighboring gene Sharpr-MPRA regulatory region 14831 Neighboring gene MPRA-validated peak5261 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:59063568-59064767 Neighboring gene uncharacterized LOC105378988 Neighboring gene NANOG hESC enhancer GRCh37_chr5:59096304-59096834 Neighboring gene uncharacterized LOC107986350 Neighboring gene NANOG hESC enhancer GRCh37_chr5:59165165-59165666 Neighboring gene microRNA 582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:59345282-59345782 Neighboring gene NANOG hESC enhancer GRCh37_chr5:59657334-59657835 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:59666235-59667434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22584 Neighboring gene RNA, U6 small nuclear 806, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:59710708-59711366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22587 Neighboring gene Sharpr-MPRA regulatory region 9229 Neighboring gene ribosomal protein L31 pseudogene 8 Neighboring gene SET pseudogene 21 Neighboring gene Sharpr-MPRA regulatory region 1909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16038 Neighboring gene uncharacterized LOC124900982 Neighboring gene prostate androgen-regulated transcript 1 Neighboring gene DEP domain containing 1B Neighboring gene calcium binding protein 39 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth. Jeong MH, et al. JCI Insight, 2023 Jul 10. PMID 37427586, Free PMC Article
  2. The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease. Yan L, et al. Cell Mol Biol (Noisy-le-grand), 2022 Feb 27. PMID 35818218
  3. Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis. Xu C, et al. Neuroradiology, 2022 Sep. PMID 35420310
  4. A novel variant in the PDE4D gene is the cause of Acrodysostosis type 2 in a Lithuanian patient: a case report. Petraitytė G, et al. BMC Endocr Disord, 2021 Apr 15. PMID 33858404, Free PMC Article
  5. Associations between SNP83 of phosphodiesterase 4D gene and carotid atherosclerosis in a southern Chinese Han population: a case-control study. Liu LY, et al. Mamm Genome, 2021 Apr. PMID 33755782

See all (246) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.
    Title: GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.
  2. Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.
    Title: Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.
  3. PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis.
    Title: PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis.
  4. Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis.
    Title: Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis.
  5. [Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population].
    Title: [Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population].
  6. PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children.
    Title: PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children.
  7. Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
    Title: Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
  8. Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.
    Title: Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.
  9. Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.
    Title: Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.
  10. The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease.
    Title: The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease.
Submit: New GeneRIF Correction See all GeneRIFs (154)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Acrodysostosis 2 with or without hormone resistance
MedGen: C3553250 OMIM: 614613 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2018-02-02)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2018-02-02)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A whole genome association study of neuroticism using DNA pooling.
EBI GWAS Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
EBI GWAS Catalog
Genome-wide association of sleep and circadian phenotypes.
EBI GWAS Catalog
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
EBI GWAS Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
EBI GWAS Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ97311, DKFZp686M11213

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity TAS
Traceable Author Statement
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables beta-2 adrenergic receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cAMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables heterocyclic compound binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adrenergic receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of endothelial barrier ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-5 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cardiac muscle cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of calcium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Names
cAMP-specific phosphodiesterase PDE4D6
phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
testicular tissue protein Li 136
NP_001098101.1
NP_001159371.1
NP_001184147.1
NP_001184148.1
NP_001184149.1
NP_001184150.1
NP_001184151.1
NP_001184152.1
NP_001336170.1
NP_001336171.1
NP_001336172.1
NP_001351528.1
NP_001351529.1
NP_001351530.1
NP_001351531.1
NP_001351532.1
NP_001351533.1
NP_006194.2
XP_011541771.1
XP_011541775.1
XP_016865055.1
XP_016865056.1
XP_024301878.1
XP_024301880.1
XP_047273249.1
XP_047273250.1
XP_047273251.1
XP_047273252.1
XP_047273253.1
XP_047273254.1
XP_047273255.1
XP_047273256.1
XP_047273257.1
XP_054208753.1
XP_054208754.1
XP_054208755.1
XP_054208756.1
XP_054208757.1
XP_054208758.1
XP_054208759.1
XP_054208760.1
XP_054208761.1
XP_054208762.1
XP_054208763.1
XP_054208764.1
XP_054208765.1
XP_054208766.1
XP_054208767.1
XP_054208768.1
XP_054208769.1
XP_054208770.1
XP_054208771.1
XP_054208772.1
XP_054208773.1
XP_054208774.1
XP_054208775.1
XP_054208776.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027957.2 RefSeqGene

    Range
    635604..1560292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104631.2 → NP_001098101.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4

    See identical proteins and their annotated locations for NP_001098101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (PDE4D4, also known as isoform 1).
    Source sequence(s)
    AC027322, AC092343, BF197530, L20969
    Consensus CDS
    CCDS47213.1
    UniProtKB/Swiss-Prot
    O43433, Q08499, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q96HL4, Q9HCX7
    UniProtKB/TrEMBL
    A0A140VJR0
    Related
    ENSP00000345502.6, ENST00000340635.11
    Conserved Domains (1) summary
    pfam00233
    Location:461 → 702
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_001165899.2 → NP_001159371.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D7

    See identical proteins and their annotated locations for NP_001159371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D7 (also known as isoform 3) has a shorter and distinct N-terminus, compared to isoform PDE4D4. Variants 3 and 13 both encode the same isoform (PDE4D7).
    Source sequence(s)
    AC092343, AY245866, BI492585, DB230503
    Consensus CDS
    CCDS54859.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000423094.2, ENST00000502484.6
    Conserved Domains (2) summary
    pfam00233
    Location:400 → 641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162 → 278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  3. NM_001197218.2 → NP_001184147.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D5

    See identical proteins and their annotated locations for NP_001184147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D5 (also known as isoform 4) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC027322, AC092343, AF012073, BF197530
    Consensus CDS
    CCDS56373.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000424852.1, ENST00000507116.6
    Conserved Domains (2) summary
    pfam00233
    Location:397 → 638
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:159 → 275
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  4. NM_001197219.2 → NP_001184148.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D8

    See identical proteins and their annotated locations for NP_001184148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D8 (also known as isoform 5) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC008791, AC092343, AF012073, AF536977, BF197530
    Consensus CDS
    CCDS56372.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000384806.2, ENST00000405755.6
    Conserved Domains (1) summary
    pfam00233
    Location:339 → 576
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. NM_001197220.2 → NP_001184149.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D9

    See identical proteins and their annotated locations for NP_001184149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D9 (also known as isoform 6) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF012073, AY245867, BF197530
    Consensus CDS
    CCDS56371.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000425605.1, ENST00000503258.5
    Conserved Domains (2) summary
    pfam00233
    Location:331 → 572
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:93 → 209
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  6. NM_001197221.2 → NP_001184150.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D2

    See identical proteins and their annotated locations for NP_001184150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D2 (also known as isoform 7) is shorter at the N-terminus, compared to isoform PDE4D4. Variants 7 and 17 both encode the same isoform (PDE4D2).
    Source sequence(s)
    AC092343, AF012074, BF197530
    Consensus CDS
    CCDS56370.1
    UniProtKB/TrEMBL
    D6RHE0
    Related
    ENSP00000351800.6, ENST00000358923.10
    Conserved Domains (2) summary
    pfam00233
    Location:159 → 400
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 37
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  7. NM_001197222.2 → NP_001184151.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D1

    See identical proteins and their annotated locations for NP_001184151.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D1 (also known as isoform 8) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF012074, BF197530, U50157
    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (1) summary
    pfam00233
    Location:237 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  8. NM_001197223.2 → NP_001184152.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D6

    See identical proteins and their annotated locations for NP_001184152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D6 (also known as isoform 9) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF536975, BC036319, BF197530
    Consensus CDS
    CCDS56369.1
    UniProtKB/TrEMBL
    D6RHE0
    Related
    ENSP00000321739.8, ENST00000317118.12
    Conserved Domains (2) summary
    pfam00233
    Location:170 → 411
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:16 → 48
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  9. NM_001349241.2 → NP_001336170.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding region, compared to variant 1. Isoform 10 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC091955, AC092343, AY245866, BI492585, DB230503
    Conserved Domains (2) summary
    pfam00233
    Location:390 → 631
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:152 → 268
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  10. NM_001349242.2 → NP_001336171.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding region, compared to variant 1. Isoform 11 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC008791, AC092343, AC117527, BF197530, L20970, U50159
    Consensus CDS
    CCDS87297.1
    UniProtKB/TrEMBL
    A0A1B0GW84
    Related
    ENSP00000490821.1, ENST00000636120.1
    Conserved Domains (2) summary
    pfam00233
    Location:351 → 592
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:113 → 229
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  11. NM_001349243.2 → NP_001336172.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and coding region, compared to variant 1. Isoform 12 is shorter and has a distinct N-terminus, compared to isoform PDE4D4. Variants 12 and 18 both encode the same isoform (12).
    Source sequence(s)
    AC091955, AC092343, AY245866, BI492585, DB230503
    Conserved Domains (2) summary
    pfam00233
    Location:205 → 446
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 83
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  12. NM_001364599.1 → NP_001351528.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 3, encodes isoform PDE4D7.
    Source sequence(s)
    AC008818, AC008829, AC008934, AC091955, AC092343
    Consensus CDS
    CCDS54859.1
    Conserved Domains (2) summary
    pfam00233
    Location:400 → 641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162 → 278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  13. NM_001364600.2 → NP_001351529.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC008829, AC008934, AC091955, AC109486

  14. NM_001364601.1 → NP_001351530.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC008829, AC027322

  15. NM_001364602.2 → NP_001351531.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC008829, AC027322, BC008390
    Consensus CDS
    CCDS93714.1
    Related
    ENSP00000425917.1, ENST00000502575.1
    Conserved Domains (1) summary
    pfam18100
    Location:159 → 204
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  16. NM_001364603.1 → NP_001351532.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 7, encodes isoform PDE4D2.
    Source sequence(s)
    AC027322, AC092343, AJ250854
    Consensus CDS
    CCDS56370.1
    UniProtKB/TrEMBL
    D6RHE0
    Conserved Domains (2) summary
    pfam00233
    Location:159 → 400
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 37
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  17. NM_001364604.1 → NP_001351533.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 12, encodes isoform 12.
    Source sequence(s)
    AC008829, AC092343, AC117527
    Conserved Domains (2) summary
    pfam00233
    Location:205 → 446
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 83
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  18. NM_006203.5 → NP_006194.2  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D3

    See identical proteins and their annotated locations for NP_006194.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D3 (also known as isoform 2) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AC117527, BF197530, L20970, U50159
    Consensus CDS
    CCDS54858.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000353152.5, ENST00000360047.9
    Conserved Domains (2) summary
    pfam00233
    Location:325 → 566
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:87 → 203
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    58969038..60522128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446112.2 → XP_024301880.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

    Conserved Domains (2) summary
    pfam00233
    Location:400 → 641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162 → 278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. XM_024446110.2 → XP_024301878.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:449 → 686
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. XM_047417295.1 → XP_047273251.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X4

  4. XM_017009566.1 → XP_016865055.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (2) summary
    pfam00233
    Location:400 → 641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162 → 278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  5. XM_047417294.1 → XP_047273250.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  6. XM_011543473.2 → XP_011541775.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

    See identical proteins and their annotated locations for XP_011541775.1

    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (2) summary
    pfam00233
    Location:400 → 641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162 → 278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  7. XM_047417293.1 → XP_047273249.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  8. XM_011543469.2 → XP_011541771.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

    See identical proteins and their annotated locations for XP_011541771.1

    Conserved Domains (1) summary
    pfam00233
    Location:449 → 686
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  9. XM_017009567.1 → XP_016865056.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3

    Conserved Domains (2) summary
    pfam00233
    Location:395 → 636
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:157 → 273
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  10. XM_047417297.1 → XP_047273253.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X6

  11. XM_047417296.1 → XP_047273252.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X5

  12. XM_047417298.1 → XP_047273254.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X7

  13. XM_047417299.1 → XP_047273255.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X7

  14. XM_047417301.1 → XP_047273257.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X9

  15. XM_047417300.1 → XP_047273256.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    59787596..61345916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352788.1 → XP_054208763.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  2. XM_054352780.1 → XP_054208755.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

  3. XM_054352789.1 → XP_054208764.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  4. XM_054352790.1 → XP_054208765.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  5. XM_054352793.1 → XP_054208768.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  6. XM_054352782.1 → XP_054208757.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

  7. XM_054352781.1 → XP_054208756.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

  8. XM_054352783.1 → XP_054208758.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

  9. XM_054352785.1 → XP_054208760.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  10. XM_054352792.1 → XP_054208767.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  11. XM_054352795.1 → XP_054208770.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X4

  12. XM_054352784.1 → XP_054208759.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  13. XM_054352778.1 → XP_054208753.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

  14. XM_054352787.1 → XP_054208762.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  15. XM_054352791.1 → XP_054208766.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  16. XM_054352779.1 → XP_054208754.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

  17. XM_054352786.1 → XP_054208761.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

  18. XM_054352794.1 → XP_054208769.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3

  19. XM_054352799.1 → XP_054208774.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X6

  20. XM_054352798.1 → XP_054208773.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X5

  21. XM_054352797.1 → XP_054208772.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X5

  22. XM_054352796.1 → XP_054208771.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X10

  23. XM_054352800.1 → XP_054208775.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X7

  24. XM_054352801.1 → XP_054208776.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08499.2 GenPept UniProtKB/Swiss-Prot:Q08499

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