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ARHGEF1 Rho guanine nucleotide exchange factor 1 [ Bos taurus (cattle) ]

Gene ID: 513377, updated on 5-Mar-2024

Summary

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Official Symbol
ARHGEF1provided by VGNC
Official Full Name
Rho guanine nucleotide exchange factor 1provided by VGNC
Primary source
VGNC:VGNC:52179
See related
BGD:BT16619; Ensembl:ENSBTAG00000018912
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (51323355..51343972, complement)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene Rab acceptor 1 Neighboring gene ETS repressor factor like Neighboring gene CD79a molecule Neighboring gene ribosomal protein S19

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 1
Names
Rho guanine nucleotide exchange factor (GEF) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    51323355..51343972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024979114.2 → XP_024834882.1  rho guanine nucleotide exchange factor 1 isoform X3

    UniProtKB/TrEMBL
    E1BG38
    Related
    ENSBTAP00000094605.1, ENSBTAT00000113445.1
    Conserved Domains (4) summary
    smart00325
    Location:539 → 722
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03169
    Location:405 → 524
    PHA03169; hypothetical protein; Provisional
    cd14679
    Location:757 → 881
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    cl02565
    Location:173 → 365
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. XM_024979112.2 → XP_024834880.1  rho guanine nucleotide exchange factor 1 isoform X2

    UniProtKB/TrEMBL
    E1BG38
    Related
    ENSBTAP00000025175.7, ENSBTAT00000025175.7
    Conserved Domains (4) summary
    smart00325
    Location:595 → 778
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14679
    Location:813 → 937
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    cl02565
    Location:173 → 365
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28033
    Location:434 → 580
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  3. XM_010815120.4 → XP_010813422.2  rho guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    E1BG38
    Related
    ENSBTAP00000057049.2, ENSBTAT00000066417.2
    Conserved Domains (4) summary
    smart00325
    Location:599 → 782
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14679
    Location:817 → 941
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    cl02565
    Location:173 → 365
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl26386
    Location:392 → 585
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  4. XM_024979121.2 → XP_024834889.1  rho guanine nucleotide exchange factor 1 isoform X5

    UniProtKB/TrEMBL
    E1BG38
    Related
    ENSBTAP00000099262.1, ENSBTAT00000122476.1
    Conserved Domains (4) summary
    smart00325
    Location:419 → 602
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03169
    Location:285 → 404
    PHA03169; hypothetical protein; Provisional
    cd14679
    Location:637 → 761
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    cl02565
    Location:53 → 245
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  5. XM_024979118.2 → XP_024834886.1  rho guanine nucleotide exchange factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MSE0, E1BG38
    Conserved Domains (4) summary
    smart00325
    Location:475 → 658
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14679
    Location:693 → 817
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    cl02565
    Location:53 → 245
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28033
    Location:314 → 460
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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