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TNFRSF12A TNF receptor superfamily member 12A [ Homo sapiens (human) ]

Gene ID: 51330, updated on 5-Mar-2024

Summary

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Official Symbol
TNFRSF12Aprovided by HGNC
Official Full Name
TNF receptor superfamily member 12Aprovided by HGNC
Primary source
HGNC:HGNC:18152
See related
Ensembl:ENSG00000006327 MIM:605914; AllianceGenome:HGNC:18152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FN14; CD266; TWEAKR
Summary
Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in gall bladder (RPKM 21.3), liver (RPKM 18.8) and 23 other tissues See more
Orthologs
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Genomic context

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See TNFRSF12A in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3020368..3022383)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3046940..3048955)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3070369..3072384)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3064184-3064351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3065208-3065772 Neighboring gene claudin 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3066992-3067588 Neighboring gene claudin 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3067589-3068185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3068783-3069378 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:3070698-3071897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10291 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3073371-3074015 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3074016-3074659 Neighboring gene host cell factor C1 regulator 1 Neighboring gene THO complex subunit 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3076940-3077746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3079359-3080163 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene uncharacterized LOC100128770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Activation of fibroblast growth factor-inducible 14 in the early phase of childhood IgA nephropathy. Tezuka Y, et al. PLoS One, 2021. PMID 34597335, Free PMC Article
  2. Elevated fibroblast growth factor-inducible 14 expression transforms proneural-like gliomas into more aggressive and lethal brain cancer. Connolly NP, et al. Glia, 2021 Sep. PMID 33991013, Free PMC Article
  3. Decreased expression of TNFRSF12A in thyroid gland cancer predicts poor prognosis: A study based on TCGA data. Wu ZH, et al. Medicine (Baltimore), 2020 Aug 21. PMID 32846846, Free PMC Article
  4. TWEAK/Fn14 Interaction Confers Aggressive Properties to Cutaneous Squamous Cell Carcinoma. Hu G, et al. J Invest Dermatol, 2019 Apr. PMID 30414907
  5. The TNF receptor family member Fn14 is highly expressed in recurrent glioblastoma and in GBM patient-derived xenografts with acquired temozolomide resistance. Hersh DS, et al. Neuro Oncol, 2018 Sep 3. PMID 29897522, Free PMC Article

See all (137) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis.
    Title: Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis.
  2. TWEAK and Fn14 are overexpressed in immune-mediated necrotizing myopathy: implications for muscle damage and repair.
    Title: TWEAK and Fn14 are overexpressed in immune-mediated necrotizing myopathy: implications for muscle damage and repair.
  3. Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia.
    Title: Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia.
  4. Relief of Extracellular Matrix Deposition Repression by Downregulation of IRF1-Mediated TWEAK/Fn14 Signaling in Keloids.
    Title: Relief of Extracellular Matrix Deposition Repression by Downregulation of IRF1-Mediated TWEAK/Fn14 Signaling in Keloids.
  5. TWEAK/Fn14 signaling may function as a reactive compensatory mechanism against extracellular matrix accumulation in keloid fibroblasts.
    Title: TWEAK/Fn14 signaling may function as a reactive compensatory mechanism against extracellular matrix accumulation in keloid fibroblasts.
  6. Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer.
    Title: Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer.
  7. TWEAK-Fn14 Axis Induces Calcium-Associated Autophagy and Cell Death To Control Mycobacterial Survival in Macrophages.
    Title: TWEAK-Fn14 Axis Induces Calcium-Associated Autophagy and Cell Death To Control Mycobacterial Survival in Macrophages.
  8. The TWEAK/Fn14/CD163 axis-implications for metabolic disease.
    Title: The TWEAK/Fn14/CD163 axis-implications for metabolic disease.
  9. BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells.
    Title: BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells.
  10. Elevated fibroblast growth factor-inducible 14 expression transforms proneural-like gliomas into more aggressive and lethal brain cancer.
    Title: Elevated fibroblast growth factor-inducible 14 expression transforms proneural-like gliomas into more aggressive and lethal brain cancer.
Submit: New GeneRIF Correction See all GeneRIFs (119)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 12A
Names
FGF-inducible 14
fibroblast growth factor-inducible immediate-early response protein 14
tweak-receptor
type I transmembrane protein Fn14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016639.3 → NP_057723.1  tumor necrosis factor receptor superfamily member 12A precursor

    See identical proteins and their annotated locations for NP_057723.1

    Status: VALIDATED

    Source sequence(s)
    BC002718
    Consensus CDS
    CCDS10489.1
    UniProtKB/Swiss-Prot
    D3DUA6, Q9HCS0, Q9NP84
    Related
    ENSP00000326737.5, ENST00000326577.9
    Conserved Domains (2) summary
    cd13413
    Location:36 → 104
    TNFRSF12A; CRD2 [structural motif]
    pfam12191
    Location:23 → 129
    stn_TNFRSF12A; tumor necrosis factor receptor stn_TNFRSF12A_TNFR domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3020368..3022383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3046940..3048955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NP84.1 GenPept UniProtKB/Swiss-Prot:Q9NP84

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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