MAP3K4 mitogen-activated protein kinase kinase kinase 4 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: MAP3K4provided by VGNC
Official Full Name: mitogen-activated protein kinase kinase kinase 4provided by VGNC
Primary source: VGNC:VGNC:31197
See related: BGD:BT23991; Ensembl:ENSBTAG00000020079
Gene type: protein coding
RefSeq status: MODEL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	9	NC_037336.1 (96674310..96779435)

Chromosome 9 - NC_037336.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

MAP3K4 (e-PCR)
- UniSTS:506451

MAP3K4 (e-PCR)
- UniSTS:278716

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase 4

XP_002690423.4

EC 2.7.11.25

XP_005211162.3

EC 2.7.11.25

XP_059745962.1

EC 2.7.11.25

XP_059745964.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

Range

96674310..96779435

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002690377.7 → XP_002690423.4 mitogen-activated protein kinase kinase kinase 4 isoform X1

UniProtKB/TrEMBL

A0A3Q1LSJ2

Related

ENSBTAP00000086870.1, ENSBTAT00000093164.1

Conserved Domains (1) summary

cd06626
Location:1324 → 1583

STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4
XM_059889979.1 → XP_059745962.1 mitogen-activated protein kinase kinase kinase 4 isoform X2
XM_005211105.5 → XP_005211162.3 mitogen-activated protein kinase kinase kinase 4 isoform X3

UniProtKB/TrEMBL

A0A3Q1MAA5

Related

ENSBTAP00000067143.2, ENSBTAT00000074485.2

Conserved Domains (1) summary

cd06626
Location:1281 → 1540

STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4
XM_059889981.1 → XP_059745964.1 mitogen-activated protein kinase kinase kinase 4 isoform X4

Related

ENSBTAP00000066441.2, ENSBTAT00000068476.2