ARHGEF11 Rho guanine nucleotide exchange factor 11 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ARHGEF11provided by VGNC
Official Full Name: Rho guanine nucleotide exchange factor 11provided by VGNC
Primary source: VGNC:VGNC:54878
See related: BGD:BT30410; Ensembl:ENSBTAG00000012361
Gene type: protein coding
RefSeq status: MODEL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (13807349..13923320)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

DIK069 (e-PCR)
- UniSTS:251568

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 11

Names: Rho guanine nucleotide exchange factor (GEF) 11

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

Range

13807349..13923320

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_059884961.1 → XP_059740944.1 rho guanine nucleotide exchange factor 11 isoform X1
XM_059884963.1 → XP_059740946.1 rho guanine nucleotide exchange factor 11 isoform X3
XM_059884962.1 → XP_059740945.1 rho guanine nucleotide exchange factor 11 isoform X2
XM_059884964.1 → XP_059740947.1 rho guanine nucleotide exchange factor 11 isoform X4
XM_059884965.1 → XP_059740948.1 rho guanine nucleotide exchange factor 11 isoform X7
XM_059884966.1 → XP_059740949.1 rho guanine nucleotide exchange factor 11 isoform X8

Related

ENSBTAP00000074205.2, ENSBTAT00000066742.2
XM_024989921.2 → XP_024845689.1 rho guanine nucleotide exchange factor 11 isoform X5

UniProtKB/TrEMBL

F1MZW2

Conserved Domains (5) summary

cd08753
Location:334 → 478

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

cd00160
Location:780 → 966

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:50 → 124

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:984 → 1126

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

cl28033
Location:1266 → 1566

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_024989923.2 → XP_024845691.1 rho guanine nucleotide exchange factor 11 isoform X6

UniProtKB/TrEMBL

F1MZW2

Related

ENSBTAP00000058487.2, ENSBTAT00000077218.2

Conserved Domains (5) summary

cd08753
Location:329 → 473

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

cd00160
Location:775 → 961

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:45 → 119

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:979 → 1121

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

cl28033
Location:1261 → 1561

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region