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STAT1 signal transducer and activator of transcription 1 [ Bos taurus (cattle) ]

Gene ID: 510814, updated on 11-Apr-2024

Summary

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Official Symbol
STAT1provided by VGNC
Official Full Name
signal transducer and activator of transcription 1provided by VGNC
Primary source
VGNC:VGNC:56151
See related
BGD:BT10969; Ensembl:ENSBTAG00000007867
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See STAT1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (79517714..79560105, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene testis expressed 51 Neighboring gene glutaminase Neighboring gene uncharacterized LOC104971266 Neighboring gene signal transducer and activator of transcription 4 Neighboring gene myosin IB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of STAT1 expression and biological activity reveals interferon-tau-dependent STAT1-regulated SOCS genes in the bovine endometrium. Vitorino Carvalho A, et al. Reprod Fertil Dev, 2016 Mar. PMID 25116692
  2. Effects of the signal transducer and activator of transcription 1 (STAT1) gene on milk production traits in Holstein dairy cattle. Cobanoglu O, et al. J Dairy Sci, 2006 Nov. PMID 17033032
  3. Bta-miR-2890 up-regulates JAK-STAT pathway to inhibit BoHV-1 replication by targeting viral gene UL41. Ma W, et al. Vet Microbiol, 2020 Jun. PMID 32456827
  4. Effects of signal transducer and activator of transcription (STAT) genes STAT1 and STAT3 genotypic combinations on fertilization and embryonic survival rates in Holstein cattle. Khatib H, et al. J Dairy Sci, 2009 Dec. PMID 19923622
  5. Interferon-alpha signalling in bovine adrenal chromaffin cells: involvement of signal-transducer and activator of transcription 1 and 2, extracellular signal-regulated protein kinases 1/2 and serine 31 phosphorylation of tyrosine hydroxylase. Douglas SA, et al. J Neuroendocrinol, 2009 Mar. PMID 19207826

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bta-miR-2890 up-regulates JAK-STAT pathway to inhibit BoHV-1 replication by targeting viral gene UL41.
    Title: Bta-miR-2890 up-regulates JAK-STAT pathway to inhibit BoHV-1 replication by targeting viral gene UL41.
  2. Report interferon-tau dependent STAT1 regulation of SOCS genes in bovine endometrium during estrus cycle and embryo implantation.
    Title: Analysis of STAT1 expression and biological activity reveals interferon-tau-dependent STAT1-regulated SOCS genes in the bovine endometrium.
  3. the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
    Title: Effects of signal transducer and activator of transcription (STAT) genes STAT1 and STAT3 genotypic combinations on fertilization and embryonic survival rates in Holstein cattle.
  4. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2.
    Title: Interferon-alpha signalling in bovine adrenal chromaffin cells: involvement of signal-transducer and activator of transcription 1 and 2, extracellular signal-regulated protein kinases 1/2 and serine 31 phosphorylation of tyrosine hydroxylase.
  5. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein synthesis and fat metabolism.
    Title: Effects of the signal transducer and activator of transcription 1 (STAT1) gene on milk production traits in Holstein dairy cattle.
  6. results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
    Title: JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 1-alpha/beta
Names
signal transducer and activator of transcription 1, 91kDa
transcription factor ISGF-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077900.1 → NP_001071368.1  signal transducer and activator of transcription 1-alpha/beta

    See identical proteins and their annotated locations for NP_001071368.1

    Status: PROVISIONAL

    Source sequence(s)
    AY488117
    UniProtKB/TrEMBL
    E1BPP7, Q05FF2
    Related
    ENSBTAP00000010351.7, ENSBTAT00000010351.7
    Conserved Domains (4) summary
    cd10372
    Location:557 → 707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:139 → 315
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:317 → 566
    STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    79517714..79560105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025000697.2 → XP_024856465.1  signal transducer and activator of transcription 1-alpha/beta isoform X1

    UniProtKB/TrEMBL
    A0A3S5ZPJ6, E1BPP7
    Conserved Domains (5) summary
    cd10372
    Location:557 → 707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:139 → 315
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:317 → 566
    STAT_bind; STAT protein, DNA binding domain
    pfam12162
    Location:715 → 739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain

  2. XM_025000682.2 → XP_024856450.1  signal transducer and activator of transcription 1-alpha/beta isoform X2

    UniProtKB/TrEMBL
    E1BPP7
    Conserved Domains (5) summary
    cd10372
    Location:557 → 706
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:139 → 315
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:317 → 566
    STAT_bind; STAT protein, DNA binding domain
    pfam12162
    Location:714 → 738
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain

  3. XM_005202570.5 → XP_005202627.2  signal transducer and activator of transcription 1-alpha/beta isoform X1

    See identical proteins and their annotated locations for XP_005202627.2

    UniProtKB/TrEMBL
    A0A3S5ZPJ6, E1BPP7
    Related
    ENSBTAP00000053390.4, ENSBTAT00000061553.4
    Conserved Domains (5) summary
    cd10372
    Location:557 → 707
    SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:139 → 315
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:317 → 566
    STAT_bind; STAT protein, DNA binding domain
    pfam12162
    Location:715 → 739
    STAT1_TAZ2bind; STAT1 TAZ2 binding domain
Nucleotide Protein Strain
Heading Accession and Version

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