ADCY6 adenylate cyclase 6 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ADCY6provided by VGNC
Official Full Name: adenylate cyclase 6provided by VGNC
Primary source: VGNC:VGNC:25647
See related: BGD:BT15041; Ensembl:ENSBTAG00000005464
Gene type: protein coding
RefSeq status: INFERRED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (30987950..31009389)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

co-localization of multiple signaling components in lipid rafts provides key spatial regulation of AC6 (ADCY6) activity.
Title: Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes.

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General gene information

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Markers

MARC_42809-42810:1097692895:1 (e-PCR)
- UniSTS:467463

MARC_42844-42845:1097694347:1 (e-PCR)
- UniSTS:467472

MARC_42863-42864:1094825350:1 (e-PCR)
- UniSTS:467480

MARC_42881-42882:1097692193:1 (e-PCR)
- UniSTS:467487

MARC_42885-42886:1097689924:1 (e-PCR)
- UniSTS:467489

MARC_10167-10168:1008702280:3 (e-PCR)
- UniSTS:528230

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: adenylate cyclase type 6

NP_001137349.1

EC 4.6.1.1

XP_010803264.1

EC 4.6.1.1

XP_024847351.1

EC 4.6.1.1

XP_024847352.1

EC 4.6.1.1

XP_059742241.1

EC 4.6.1.1

XP_059742242.1

EC 4.6.1.1

XP_059742243.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143877.1 → NP_001137349.1 adenylate cyclase type 6

See identical proteins and their annotated locations for NP_001137349.1

Status: INFERRED

Source sequence(s)

NKLS02000005

UniProtKB/TrEMBL

E1B9K3

Related

ENSBTAP00000089770.1, ENSBTAT00000117179.1

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:16 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

Range

30987950..31009389

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010804962.4 → XP_010803264.1 adenylate cyclase type 6 isoform X1

See identical proteins and their annotated locations for XP_010803264.1

UniProtKB/TrEMBL

E1B9K3

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:16 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_024991584.2 → XP_024847352.1 adenylate cyclase type 6 isoform X1

UniProtKB/TrEMBL

E1B9K3

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:16 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_024991583.2 → XP_024847351.1 adenylate cyclase type 6 isoform X1

UniProtKB/TrEMBL

E1B9K3

Related

ENSBTAP00000007187.4, ENSBTAT00000007187.6

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:16 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_059886258.1 → XP_059742241.1 adenylate cyclase type 6 isoform X1

UniProtKB/TrEMBL

E1B9K3
XM_059886259.1 → XP_059742242.1 adenylate cyclase type 6 isoform X2
XM_059886260.1 → XP_059742243.1 adenylate cyclase type 6 isoform X3