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Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like [ Mus musculus (house mouse) ]

Gene ID: 50926, updated on 11-Apr-2024

Summary

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Official Symbol
Hnrnpdlprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein D-likeprovided by MGI
Primary source
MGI:MGI:1355299
See related
Ensembl:ENSMUSG00000029328 AllianceGenome:MGI:1355299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JKTBP; Hnrpdl; Hnrnpdl1; hnRNP DL; hnRNP-DL; D5Wsu145e; D5Ertd650e
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within mRNA metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 3. Orthologous to human HNRNPDL (heterogeneous nuclear ribonucleoprotein D like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 88.2), CNS E14 (RPKM 86.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Hnrnpdl in Genome Data Viewer
Location:
5 E4; 5 48.46 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100181436..100187769, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100033577..100039936, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene RIKEN cDNA 4930524J08 gene Neighboring gene STARR-seq mESC enhancer starr_13719 Neighboring gene predicted gene, 42127 Neighboring gene STARR-positive B cell enhancer ABC_E2161 Neighboring gene STARR-seq mESC enhancer starr_13720 Neighboring gene enolase-phosphatase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8822 Neighboring gene transmembrane protein 150C, opposite strand Neighboring gene transmembrane protein 150C Neighboring gene predicted gene, 36167

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a mouse heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its tissue-specific expression. Akagi T, et al. Gene, 2000 Mar 21. PMID 10717477
  2. Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor. Boopathi E, et al. J Biol Chem, 2004 Aug 20. PMID 15190078
  3. Cloning and characterization of a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein-like protein and its expression in myeloid leukemia cells. Tsuchiya N, et al. J Biochem, 1998 Mar. PMID 9538234
  4. NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element. Reboll MR, et al. RNA, 2007 Aug. PMID 17592041, Free PMC Article
  5. Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. Sheehan CJ, et al. Development, 2020 Jan 13. PMID 31857347, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(G) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(G) binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein D-like
Names
JKT41-binding protein
hnRNP D-like
hnRPD-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405515.1 → NP_001392444.1  heterogeneous nuclear ribonucleoprotein D-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124480
    UniProtKB/TrEMBL
    D3YTQ3

  2. NM_001405516.1 → NP_001392445.1  heterogeneous nuclear ribonucleoprotein D-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124480

  3. NM_001405517.1 → NP_001392446.1  heterogeneous nuclear ribonucleoprotein D-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124480

  4. NM_001405518.1 → NP_001392447.1  heterogeneous nuclear ribonucleoprotein D-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124480
    Related
    ENSMUSP00000118555.2, ENSMUST00000153442.8

  5. NM_001405519.1 → NP_001392448.1  heterogeneous nuclear ribonucleoprotein D-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124480

  6. NM_016690.5 → NP_057899.2  heterogeneous nuclear ribonucleoprotein D-like isoform 1

    See identical proteins and their annotated locations for NP_057899.2

    Status: VALIDATED

    Source sequence(s)
    AC124480
    Consensus CDS
    CCDS19460.2
    UniProtKB/TrEMBL
    D3YTQ3
    Related
    ENSMUSP00000121005.2, ENSMUST00000128187.8
    Conserved Domains (2) summary
    cd12585
    Location:234 → 308
    RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
    cd12758
    Location:149 → 224
    RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

RNA

  1. NR_152866.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124480

  2. NR_175955.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124480

  3. NR_175956.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124480

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100181436..100187769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535076.5 → XP_006535139.1  heterogeneous nuclear ribonucleoprotein D-like isoform X2

    See identical proteins and their annotated locations for XP_006535139.1

    Conserved Domains (2) summary
    cd12585
    Location:234 → 308
    RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
    cd12758
    Location:149 → 224
    RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z130.1 GenPept UniProtKB/Swiss-Prot:Q9Z130

Gene LinkOut

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