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MAP3K3 mitogen-activated protein kinase kinase kinase 3 [ Bos taurus (cattle) ]

Gene ID: 508943, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K3provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 3provided by VGNC
Primary source
VGNC:VGNC:31196
See related
Ensembl:ENSBTAG00000008151
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (47912553..47973780)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of cytochrome c oxidase I Neighboring gene basic proline-rich protein-like Neighboring gene LIM domain containing 2 Neighboring gene STE20 related adaptor alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 3
XP_002696140.2
XP_005221038.1
XP_005221041.1
XP_010814736.1
XP_059734557.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    47912553..47973780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059878574.1 → XP_059734557.1  mitogen-activated protein kinase kinase kinase 3 isoform X3

    Related
    ENSBTAP00000091421.1, ENSBTAT00000089639.1

  2. XM_005220981.5 → XP_005221038.1  mitogen-activated protein kinase kinase kinase 3 isoform X1

    See identical proteins and their annotated locations for XP_005221038.1

    UniProtKB/TrEMBL
    A0A3Q1LPF2
    Related
    ENSBTAP00000058887.1, ENSBTAT00000081015.2
    Conserved Domains (3) summary
    cd06405
    Location:76 → 154
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:393 → 652
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06625
    Location:392 → 652
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

  3. XM_010816434.4 → XP_010814736.1  mitogen-activated protein kinase kinase kinase 3 isoform X2

    See identical proteins and their annotated locations for XP_010814736.1

    Conserved Domains (3) summary
    cd06405
    Location:76 → 154
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:389 → 648
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06625
    Location:388 → 648
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

  4. XM_002696094.7 → XP_002696140.2  mitogen-activated protein kinase kinase kinase 3 isoform X4

    See identical proteins and their annotated locations for XP_002696140.2

    UniProtKB/TrEMBL
    F1MH06
    Related
    ENSBTAP00000088066.1, ENSBTAT00000114375.1
    Conserved Domains (3) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:362 → 621
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06625
    Location:361 → 621
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

  5. XM_005220984.5 → XP_005221041.1  mitogen-activated protein kinase kinase kinase 3 isoform X5

    See identical proteins and their annotated locations for XP_005221041.1

    Related
    ENSBTAP00000010716.7, ENSBTAT00000010716.7
    Conserved Domains (3) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:358 → 617
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06625
    Location:357 → 617
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases
Nucleotide Protein Strain
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