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PLCB2 phospholipase C beta 2 [ Bos taurus (cattle) ]

Gene ID: 508888, updated on 3-Apr-2024

Summary

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Official Symbol
PLCB2provided by VGNC
Official Full Name
phospholipase C beta 2provided by VGNC
Primary source
VGNC:VGNC:32981
See related
Ensembl:ENSBTAG00000019079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (35906038..35927096, complement)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene ankyrin repeat domain 63 Neighboring gene InaF motif containing 2 Neighboring gene coiled-coil domain containing 9B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
NP_001178330.1
XP_024853150.1
XP_024853151.1
XP_024853152.1
XP_024853154.1
XP_059746280.1
XP_059746281.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191401.1 → NP_001178330.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

    Status: VALIDATED

    Source sequence(s)
    CF765769, NKLS02000010
    UniProtKB/TrEMBL
    E1B7M6
    Related
    ENSBTAP00000025402.6, ENSBTAT00000025402.7
    Conserved Domains (7) summary
    cd00275
    Location:679 → 800
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:310 → 647
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02222
    Location:218 → 798
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:999 → 1153
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:219 → 310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl03951
    Location:1021 → 1118
    CDC37_N; Cdc37 N terminal kinase binding

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    35906038..35927096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024997382.2 → XP_024853150.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LQG3, E1B7M6
    Conserved Domains (5) summary
    cd00275
    Location:679 → 800
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:310 → 647
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:985 → 1139
    PLC-beta_C; PLC-beta C terminal
    cd16209
    Location:148 → 298
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

  2. XM_059890297.1 → XP_059746280.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

  3. XM_024997383.2 → XP_024853151.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

    UniProtKB/TrEMBL
    E1B7M6
    Conserved Domains (4) summary
    cd00275
    Location:679 → 800
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:310 → 647
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16209
    Location:148 → 298
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

  4. XM_059890298.1 → XP_059746281.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

  5. XM_024997384.2 → XP_024853152.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

    Conserved Domains (3) summary
    cd08624
    Location:310 → 647
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16209
    Location:148 → 298
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

  6. XM_024997386.2 → XP_024853154.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6

    Conserved Domains (3) summary
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd15898
    Location:148 → 177
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:148 → 193
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
Nucleotide Protein Strain
Heading Accession and Version

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