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STAT3 signal transducer and activator of transcription 3 [ Bos taurus (cattle) ]

Gene ID: 508541, updated on 13-Apr-2024

Summary

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Official Symbol
STAT3provided by VGNC
Official Full Name
signal transducer and activator of transcription 3provided by VGNC
Primary source
VGNC:VGNC:35371
See related
BGD:BT11963; Ensembl:ENSBTAG00000021523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (42417946..42491782, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene signal transducer and activator of transcription 5A Neighboring gene caveolae associated protein 1 Neighboring gene cyclin-G1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic Variants in STAT3 Promoter Regions and Their Application in Molecular Breeding for Body Size Traits in Qinchuan Cattle. Wu S, et al. Int J Mol Sci, 2018 Mar 29. PMID 29596388, Free PMC Article
  2. Shear flow attenuates serum-induced STAT3 activation in endothelial cells. Ni CW, et al. J Biol Chem, 2003 May 30. PMID 12637510
  3. STAT3 signaling stimulates miR-21 expression in bovine cumulus cells during in vitro oocyte maturation. Tscherner A, et al. Sci Rep, 2018 Aug 1. PMID 30068990, Free PMC Article
  4. Prostaglandin F2α-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle. Rovani MT, et al. Mol Reprod Dev, 2017 Jun. PMID 28337827
  5. Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy. Al-Shabrawey M, et al. Invest Ophthalmol Vis Sci, 2008 Jul. PMID 18378570, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Together these studies represent the first investigation of STAT3 signaling that directly influence miR-21 expression in bovine oocytes and cumulus cells.
    Title: STAT3 signaling stimulates miR-21 expression in bovine cumulus cells during in vitro oocyte maturation.
  2. variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.
    Title: Genetic Variants in STAT3 Promoter Regions and Their Application in Molecular Breeding for Body Size Traits in Qinchuan Cattle.
  3. Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
    Title: Prostaglandin F2α-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle.
  4. STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
    Title: Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
  5. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
    Title: Identification of single nucleotide polymorphisms of the signal transducer and activator of transcription 3 gene (STAT3) associated with body measurement and carcass quality traits in beef cattle.
  6. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
    Title: Effects of signal transducer and activator of transcription (STAT) genes STAT1 and STAT3 genotypic combinations on fertilization and embryonic survival rates in Holstein cattle.
  7. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3.
    Title: Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy.
  8. role of shear flow in attenuating activation in endothelial cells
    Title: Shear flow attenuates serum-induced STAT3 activation in endothelial cells.
  9. results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
    Title: JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression.
  10. peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3
    Title: Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC128731

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leptin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 3
Names
signal transducer and activator of transcription 3 (acute-phase response factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012671.2 → NP_001012689.2  signal transducer and activator of transcription 3

    See identical proteins and their annotated locations for NP_001012689.2

    Status: VALIDATED

    Source sequence(s)
    AJ620655, BC109481
    UniProtKB/Swiss-Prot
    P61635
    UniProtKB/TrEMBL
    F1MX38
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141 → 319
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:321 → 573
    STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42417946..42491782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024979867.2 → XP_024835635.1  signal transducer and activator of transcription 3 isoform X4

    UniProtKB/Swiss-Prot
    P61635
    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141 → 319
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:321 → 573
    STAT_bind; STAT protein, DNA binding domain

  2. XM_010816228.4 → XP_010814530.1  signal transducer and activator of transcription 3 isoform X2

    UniProtKB/Swiss-Prot
    P61635
    Related
    ENSBTAP00000028687.6, ENSBTAT00000028687.7
    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141 → 319
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:321 → 573
    STAT_bind; STAT protein, DNA binding domain

  3. XM_024979866.2 → XP_024835634.1  signal transducer and activator of transcription 3 isoform X3

    UniProtKB/Swiss-Prot
    P61635
    UniProtKB/TrEMBL
    Q32LP6
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141 → 319
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:321 → 573
    STAT_bind; STAT protein, DNA binding domain

  4. XM_024979865.2 → XP_024835633.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/Swiss-Prot
    P61635
    UniProtKB/TrEMBL
    F1MX38
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141 → 319
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:321 → 573
    STAT_bind; STAT protein, DNA binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61635.1 GenPept UniProtKB/Swiss-Prot:P61635

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