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Nt5c 5',3'-nucleotidase, cytosolic [ Mus musculus (house mouse) ]

Gene ID: 50773, updated on 5-Mar-2024

Summary

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Official Symbol
Nt5cprovided by MGI
Official Full Name
5',3'-nucleotidase, cytosolicprovided by MGI
Primary source
MGI:MGI:1354954
See related
Ensembl:ENSMUSG00000020736 AllianceGenome:MGI:1354954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnt; Dnt1; Umph2; Umph-2
Summary
Enables IMP 5'-nucleotidase activity. Involved in allantoin metabolic process and nucleoside monophosphate catabolic process. Acts upstream of or within deoxyribonucleotide catabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and thymus. Orthologous to human NT5C (5', 3'-nucleotidase, cytosolic). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 50.2), colon adult (RPKM 41.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 80.84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115381251..115382659, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115490420..115492070, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 80 Neighboring gene microRNA 3968 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115323680-115323881 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115324075-115324262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115324966-115325149 Neighboring gene predicted gene 11695 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E5298 Neighboring gene armadillo repeat containing 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115353318-115353427 Neighboring gene ribosomal protein L39 pseudogene Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115374372-115374555 Neighboring gene STARR-positive B cell enhancer ABC_E470 Neighboring gene small ubiquitin-like modifier 2 Neighboring gene STARR-positive B cell enhancer ABC_E4015

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. [Preliminary localization of TK1 and UMPH2 genes on swine chromosome 12]. Astakhova NM, et al. Genetika, 1994 Jun. PMID 7958795
  2. Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2. Swallow DM, et al. Ann Hum Genet, 1983 Jan. PMID 6301357
  3. Provisional assignment of the gene for uridine monophosphatase-2 (Umph-2) to mouse chromosome 11. Wilson DE, et al. Biochem Genet, 1987 Feb. PMID 3034234
  4. Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells. Rampazzo C, et al. J Biol Chem, 2000 Feb 25. PMID 10681516
  5. Characterization of pig-mink cell hybrids: assignment of the TK1 and UMPH2 genes to pig chromosome 12. Zhdanova NS, et al. Mamm Genome, 1994 Dec. PMID 7894159

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables IMP 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyrimidine nucleotide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in IMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in allantoin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dCMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dGMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dTMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dUMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within deoxyribonucleotide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine deoxyribonucleotide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine deoxyribonucleotide catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
5'(3')-deoxyribonucleotidase, cytosolic type
Names
5' nucleotidase, deoxy (pyrimidine), cytosolic type C
cytosolic 5',3'-pyrimidine nucleotidase
dNT-1
deoxy-5'-nucleotidase 1
uridine monophosphatase 2
NP_001404571.1
NP_001404572.1
NP_056622.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417642.1 → NP_001404571.1  5'(3')-deoxyribonucleotidase, cytosolic type isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645470

  2. NM_001417643.1 → NP_001404572.1  5'(3')-deoxyribonucleotidase, cytosolic type isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645470
    UniProtKB/TrEMBL
    A2A9X5
    Related
    ENSMUSP00000102140.2, ENSMUST00000106530.8

  3. NM_015807.2 → NP_056622.1  5'(3')-deoxyribonucleotidase, cytosolic type isoform 1

    See identical proteins and their annotated locations for NP_056622.1

    Status: VALIDATED

    Source sequence(s)
    AL645470
    Consensus CDS
    CCDS25637.1
    UniProtKB/Swiss-Prot
    Q9JM14
    Related
    ENSMUSP00000021082.7, ENSMUST00000021082.7
    Conserved Domains (1) summary
    cl21460
    Location:5 → 196
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

  1. NR_184549.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645470

  2. NR_184550.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645470

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115381251..115382659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JM14.1 GenPept UniProtKB/Swiss-Prot:Q9JM14

Gene LinkOut

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