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PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 [ Bos taurus (cattle) ]

Gene ID: 507414, updated on 3-Apr-2024

Summary

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Official Symbol
PIK3R4provided by VGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 4provided by VGNC
Primary source
VGNC:VGNC:32895
See related
BGD:BT16549; Ensembl:ENSBTAG00000020787
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PIK3R4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (151476132..151562596)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346086 Neighboring gene uncharacterized LOC132346085 Neighboring gene collagen type VI alpha 6 chain Neighboring gene collagen type VI alpha 5 chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy of peroxisome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in late endosome to vacuole transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in macroautophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein targeting to vacuole IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus-vacuole junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class III, type I IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class III, type II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphoinositide 3-kinase regulatory subunit 4
NP_001093784.1
XP_005202187.1
XP_024856833.1
XP_059730433.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100314.2 → NP_001093784.1  phosphoinositide 3-kinase regulatory subunit 4

    See identical proteins and their annotated locations for NP_001093784.1

    Status: PROVISIONAL

    Source sequence(s)
    BC148105
    UniProtKB/TrEMBL
    A0A3Q1LLF0, A6QLW1
    Related
    ENSBTAP00000027702.4, ENSBTAT00000027702.5
    Conserved Domains (5) summary
    smart00320
    Location:1327 → 1358
    WD40; WD40 repeats
    cd13980
    Location:25 → 320
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    sd00044
    Location:539 → 566
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:997 → 1040
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:985 → 1269
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    151476132..151562596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005202130.4 → XP_005202187.1  phosphoinositide 3-kinase regulatory subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LLF0
    Related
    ENSBTAP00000057378.2, ENSBTAT00000086493.2
    Conserved Domains (7) summary
    COG2319
    Location:983 → 1314
    WD40; WD40 repeat [General function prediction only]
    cd13980
    Location:25 → 320
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    pfam00069
    Location:26 → 309
    Pkinase; Protein kinase domain
    pfam07539
    Location:317 → 448
    DRIM; Down-regulated in metastasis
    sd00044
    Location:539 → 566
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:997 → 1040
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:985 → 1314
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_025001065.2 → XP_024856833.1  phosphoinositide 3-kinase regulatory subunit 4 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LLF0, A0A3Q1LTG2
    Conserved Domains (5) summary
    smart00320
    Location:1269 → 1300
    WD40; WD40 repeats
    cd13980
    Location:25 → 320
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    sd00044
    Location:379 → 404
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:939 → 982
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:927 → 1211
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_059874450.1 → XP_059730433.1  phosphoinositide 3-kinase regulatory subunit 4 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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