LOC507201 phospholipase A2, group IIA (platelets, synovial fluid) [Bos taurus (cattle)] - Gene

Summary

Gene symbol: LOC507201
Gene description: phospholipase A2, group IIA (platelets, synovial fluid)
See related: BGD:BT17002
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: PLA2G2A
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (132707944..132713984)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of copy number variation of PLA2G2A gene to growth traits in Chinese cattle.
Title: Effect of copy number variation of PLA2G2A gene to growth traits in Chinese cattle.
Activation of the cytosolic calcium-independent phospholipase A2 beta isoform contributes to TRPC6 externalization via release of arachidonic acid.
Title: Activation of the cytosolic calcium-independent phospholipase A(2) β isoform contributes to TRPC6 externalization via release of arachidonic acid.
results suggest the hydrophobic surfactant protein, SP-B, protects alveolar surfactant phospholiopids from hydrolysis mediated by multiple sPLA(2) in both vesicles (alveolar subphase) and monomolecular films (air-liquid interface)
Title: Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phospholipase A2, membrane associated

Names: GIIC sPLA2; group IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A

NP_001020495.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025324.2 → NP_001020495.1 phospholipase A2, membrane associated precursor

See identical proteins and their annotated locations for NP_001020495.1

Status: PROVISIONAL

Source sequence(s)

AY911335

UniProtKB/Swiss-Prot

Q3T193, Q56JZ2

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...