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PRKCD protein kinase C delta [ Bos taurus (cattle) ]

Gene ID: 505708, updated on 3-Apr-2024

Summary

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Official Symbol
PRKCDprovided by VGNC
Official Full Name
protein kinase C deltaprovided by VGNC
Primary source
VGNC:VGNC:33329
See related
BGD:BT11517; Ensembl:ENSBTAG00000008719
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PRKCD in Genome Data Viewer
Location:
chromosome: 22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (47746199..47780550, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104975561 Neighboring gene PRELI domain containing protein 3B-like Neighboring gene uncharacterized LOC132343514 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene RFT1 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development. Yang QE, et al. Reprod Fertil Dev, 2016 Mar. PMID 25116760
  2. Protein kinase Cdelta-dependent phosphorylation of syndecan-4 regulates cell migration. Chaudhuri P, et al. Circ Res, 2005 Sep 30. PMID 16141413
  3. Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone. Budnik LT, et al. Biol Reprod, 2002 Sep. PMID 12193405
  4. Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. Yang QE, et al. Biol Reprod, 2011 May. PMID 21191110
  5. deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification. Monti M, et al. J Mol Cell Cardiol, 2010 Apr. PMID 19913548, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
    Title: The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development.
  2. investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 regulates IFNT production in trophoblasts by acting through PRKCD
    Title: Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast.
  3. deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification
    Title: deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification.
  4. Protein kinase Cdelta-dependent phosphorylation of syndecan-4 regulates cell migration.
    Title: Protein kinase Cdelta-dependent phosphorylation of syndecan-4 regulates cell migration.
  5. stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
    Title: Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C delta type
NP_001071323.1
XP_024838244.1
XP_024838246.1
XP_024838247.1
XP_024838248.1
XP_024838249.1
XP_059735496.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077855.2 → NP_001071323.1  protein kinase C delta type

    See identical proteins and their annotated locations for NP_001071323.1

    Status: PROVISIONAL

    Source sequence(s)
    BC126577
    UniProtKB/TrEMBL
    A0A3Q1MRR6, A0JN97
    Related
    ENSBTAP00000011487.6, ENSBTAT00000011487.7
    Conserved Domains (3) summary
    smart00220
    Location:349 → 603
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:231 → 283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:353 → 668
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    47746199..47780550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024982478.2 → XP_024838246.1  protein kinase C delta type isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MRR6
    Related
    ENSBTAP00000074537.2, ENSBTAT00000078659.2
    Conserved Domains (2) summary
    pfam00130
    Location:231 → 283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:364 → 679
    PKc_like; Protein Kinases, catalytic domain

  2. XM_024982481.2 → XP_024838249.1  protein kinase C delta type isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MRR6
    Conserved Domains (2) summary
    pfam00130
    Location:231 → 283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:351 → 666
    PKc_like; Protein Kinases, catalytic domain

  3. XM_024982480.2 → XP_024838248.1  protein kinase C delta type isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MRR6, F1MZX0
    Conserved Domains (2) summary
    pfam00130
    Location:231 → 283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:353 → 668
    PKc_like; Protein Kinases, catalytic domain

  4. XM_024982479.2 → XP_024838247.1  protein kinase C delta type isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MRR6
    Conserved Domains (2) summary
    pfam00130
    Location:231 → 283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:362 → 677
    PKc_like; Protein Kinases, catalytic domain

  5. XM_024982476.2 → XP_024838244.1  protein kinase C delta type isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MRR6
    Conserved Domains (2) summary
    pfam00130
    Location:231 → 283
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:364 → 679
    PKc_like; Protein Kinases, catalytic domain

  6. XM_059879513.1 → XP_059735496.1  protein kinase C delta type isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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