Smad4 SMAD family member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50554, updated on 11-Apr-2024

Summary

Official Symbol: Smad4provided by RGD
Official Full Name: SMAD family member 4provided by RGD
Primary source: RGD:3033
See related: Ensembl:ENSRNOG00000051965 AllianceGenome:RGD:3033
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Madh4
Summary: Enables DNA binding activity; SMAD binding activity; and filamin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to glucose stimulus; and positive regulation of cardiac muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study pulmonary fibrosis. Biomarker of several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); prostatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 356.1), Thymus (RPKM 335.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (69518988..69549684, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (67243742..67274438, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (69626682..69657373, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-125b aggregates osteoporosis in postmenopausal rats via targeting Smad4.
Title: MiR-125b aggregates osteoporosis in postmenopausal rats via targeting Smad4.
The results showed that Bcl6 overexpression induced decreased proliferation and reduced activation of fibroblasts which were stimulated with TGFb1. It was found that activated smad2 and smad3 were not changed by overexpressing Bcl6, but smad4 was decreased.
Title: Bcl6 Suppresses Cardiac Fibroblast Activation and Function via Directly Binding to Smad4.
Synergistic effects may exist among Smad4, Smad7 and caveolin-1 in carcinogenesis of oral cancer.
Title: [Significance of Smad4, Smad7 and Caveolin-1 expression in oral mucosa carcinogenesis of Wistar rats].
This study identified a novel role of Smad4 SUMOylation and TPM2 in learning and memory formation. These results suggest that patients with skeletal myopathies who carry the TPM2E122K mutation may also have deficits in learning and memory functions.
Title: Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2.
The results demonstrate that miR124 upregulation inhibits the growth of C6 glioma cells by targeting Smad4 directly.
Title: MicroRNA-124 inhibits the proliferation of C6 glioma cells by targeting Smad4.
Smad4-dependent TGF-beta signaling in smooth muscle cells protects against aortic aneurysm formation and dissection.
Title: Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.
These results suggest that high glucose may activate TGF- beta/Smad signaling through sumoylation of Samd4 by SUMO2/3 in mesangial cells.
Title: High glucose induces sumoylation of Smad4 via SUMO2/3 in mesangial cells.
It is a one of fibrotic genes in kidney fibrosis.
Title: Melittin inhibits TGF-β-induced pro-fibrotic gene expression through the suppression of the TGFβRII-Smad, ERK1/2 and JNK-mediated signaling pathway.
The data indicated that inhibition of Smad4 diminished both AdBMP2 induced and basal histone acetylation levels in the promoter regions of GATA4 and Nkx2.5.
Title: Smad4 mediated BMP2 signal is essential for the regulation of GATA4 and Nkx2.5 by affecting the histone H3 acetylation in H9c2 cells.
miR-146a is overexpressed in an experimentally induced osteoarthritis model, accompanied by upregulation of VEGF and downregulation of Smad4 in vivo
Title: miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Markers

D18Wsu70e (e-PCR), detects polymorphism
- UniSTS:142202

AF010230 (e-PCR)
- UniSTS:105082

PMC86557P1 (e-PCR)
- UniSTS:273533

RH129873 (e-PCR)
- UniSTS:213161

PMC324399P2 (e-PCR)
- UniSTS:273130

RH143443 (e-PCR)
- UniSTS:232690

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
contributes_to DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info
enables I-SMAD binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	IEA Inferred from Electronic Annotation more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables filamin binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sulfate binding	IEA Inferred from Electronic Annotation more info
enables sulfate binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anatomical structure morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular canal development	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular canal development	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular valve formation	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular valve formation	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in brainstem development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brainstem development	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy in response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac septum development	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in developmental growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within developmental growth	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocardial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endocardial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoderm development	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell activation	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell activation	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female gonad development	ISO Inferred from Sequence Orthology more info
involved_in female gonad morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female gonad morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in formation of anatomical boundary	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within formation of anatomical boundary	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation	ISO Inferred from Sequence Orthology more info
involved_in gastrulation with mouth forming second	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in left ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in left ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in mesendoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of mesendoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchyme morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in metanephric mesenchyme morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac myofibril assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac myofibril assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nephrogenic mesenchyme morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in nephrogenic mesenchyme morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate commitment	ISO Inferred from Sequence Orthology more info
involved_in neuron fate specification	IEA Inferred from Electronic Annotation more info
involved_in neuron fate specification	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outflow tract septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell proliferation involved in heart valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell proliferation involved in heart valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of follicle-stimulating hormone secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of luteinizing hormone secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of luteinizing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of hair follicle development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta2 production	IEA Inferred from Electronic Annotation more info
involved_in regulation of transforming growth factor beta2 production	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to transforming growth factor beta	ISO Inferred from Sequence Orthology more info
involved_in sebaceous gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sebaceous gland development	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	IEA Inferred from Electronic Annotation more info
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
involved_in seminiferous tubule development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within seminiferous tubule development	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info
involved_in somite rostral/caudal axis specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somite rostral/caudal axis specification	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in uterus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within uterus development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of SMAD protein complex	ISO Inferred from Sequence Orthology more info
part_of activin responsive factor complex	IEA Inferred from Electronic Annotation more info
part_of activin responsive factor complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
part_of chromatin	IEA Inferred from Electronic Annotation more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of heteromeric SMAD protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heteromeric SMAD protein complex	IEA Inferred from Electronic Annotation more info
part_of heteromeric SMAD protein complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mothers against decapentaplegic homolog 4

Names: MAD (mothers against decapentaplegic Drosophila) homolog 4; MAD homolog 4; SMAD 4; mothers against DPP homolog 4

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019275.3 → NP_062148.1 mothers against decapentaplegic homolog 4

See identical proteins and their annotated locations for NP_062148.1

Status: VALIDATED

Source sequence(s)

AB010954, JAXUCZ010000018

UniProtKB/Swiss-Prot

O70437

UniProtKB/TrEMBL

A0A8I5ZMM9, A6IY15

Related

ENSRNOP00000074882.2, ENSRNOT00000082484.2

Conserved Domains (2) summary

cd10492
Location:14 → 138

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

cd10498
Location:320 → 541

MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4