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MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Bos taurus (cattle) ]

Gene ID: 504592, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K2provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 2provided by VGNC
Primary source
VGNC:VGNC:31195
See related
BGD:BT13283; Ensembl:ENSBTAG00000004216
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (5150448..5248225)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene ras-related GTP-binding protein C-like Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene microRNA mir-2285aa Neighboring gene cytochrome P450 family 27 subfamily C member 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 2
XP_002685278.2
XP_059733675.1
XP_059733677.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    5150448..5248225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059877694.1 → XP_059733677.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

  2. XM_059877692.1 → XP_059733675.1  mitogen-activated protein kinase kinase kinase 2 isoform X2

  3. XM_002685232.7 → XP_002685278.2  mitogen-activated protein kinase kinase kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_002685278.2

    UniProtKB/TrEMBL
    F1MSX4
    Related
    ENSBTAP00000005525.5, ENSBTAT00000005525.6
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:354 → 617
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
Nucleotide Protein Strain
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