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PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [ Bos taurus (cattle) ]

Gene ID: 504531, updated on 3-Apr-2024

Summary

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Official Symbol
PIK3CDprovided by VGNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaprovided by VGNC
Primary source
VGNC:VGNC:32891
See related
BGD:BT19202; Ensembl:ENSBTAG00000018984
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (43788096..43849491, complement)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene catenin beta interacting protein 1 Neighboring gene calsyntenin 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC101907127 Neighboring gene 5S ribosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 201

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Names
phosphoinositide-3-kinase, catalytic, delta polypeptide
NP_001192477.1
XP_005216999.1
XP_005217000.1
XP_010811547.1
XP_010811548.1
XP_024831851.1
XP_024831852.1
XP_024831853.1
XP_024831854.1
XP_059731247.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205548.2 → NP_001192477.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000016
    UniProtKB/TrEMBL
    A0A3Q1MD55
    Conserved Domains (5) summary
    cd08693
    Location:314 → 481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504 → 684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:676 → 1042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:178 → 281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    43788096..43849491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010813246.3 → XP_010811548.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MD55
    Conserved Domains (5) summary
    cd08693
    Location:314 → 481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:505 → 683
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:675 → 1041
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:178 → 281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain

  2. XM_024976086.2 → XP_024831854.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MD55
    Related
    ENSBTAP00000068325.2, ENSBTAT00000067726.2
    Conserved Domains (5) summary
    cd08693
    Location:314 → 481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    cd05174
    Location:628 → 994
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:178 → 281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain
    cl00271
    Location:504 → 636
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  3. XM_005216942.4 → XP_005216999.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_005216999.1

    UniProtKB/TrEMBL
    A0A3Q1MD55, E1BE66
    Related
    ENSBTAP00000064363.2, ENSBTAT00000071502.2
    Conserved Domains (5) summary
    cd08693
    Location:314 → 481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504 → 684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:676 → 1042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:178 → 281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain

  4. XM_024976083.2 → XP_024831851.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MD55, E1BE66
    Conserved Domains (5) summary
    cd08693
    Location:314 → 481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504 → 684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:676 → 1042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:178 → 281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain

  5. XM_059875264.1 → XP_059731247.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    UniProtKB/TrEMBL
    E1BE66

  6. XM_010813245.4 → XP_010811547.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_010811547.1

    UniProtKB/TrEMBL
    A0A3Q1MD55, E1BE66
    Conserved Domains (5) summary
    cd08693
    Location:314 → 481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504 → 684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:676 → 1042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:178 → 281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain

  7. XM_024976084.2 → XP_024831852.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MD55
    Related
    ENSBTAP00000025274.6, ENSBTAT00000025274.6
    Conserved Domains (5) summary
    cd08693
    Location:314 → 481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:505 → 683
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:675 → 1041
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:178 → 281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain

  8. XM_005216943.5 → XP_005217000.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_005217000.1

    UniProtKB/TrEMBL
    A0A3Q1MD55, E1BE66
    Conserved Domains (5) summary
    cd08693
    Location:314 → 481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504 → 684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cd05174
    Location:676 → 1042
    PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    pfam00794
    Location:178 → 281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain

  9. XM_024976085.2 → XP_024831853.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MD55
    Conserved Domains (5) summary
    cd08693
    Location:314 → 481
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00145
    Location:504 → 684
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    pfam00794
    Location:178 → 281
    PI3K_rbd; PI3-kinase family, ras-binding domain
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain
    cl21453
    Location:676 → 999
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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