itga6a integrin, alpha 6a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itga6aprovided by ZNC
Official Full Name: integrin, alpha 6aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050309-23
See related: Ensembl:ENSDARG00000042282 AllianceGenome:ZFIN:ZDB-GENE-050309-23
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: itga6; fb80g02; im:6897425; wu:fb80g02; si:dkey-32o22.1
Summary: Acts upstream of or within skeletal muscle tissue development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Is expressed in several structures, including axial chorda mesoderm; hypodermis; retina; solid lens vesicle; and trunk. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGA6 (integrin subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (3429630..3486488)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (3458101..3514959)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

fb80g02.x1 (e-PCR)
- UniSTS:191581

fb80g02.x1 (e-PCR)
- UniSTS:191582

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-6

Names: integrin, alpha 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

3429630..3486488

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167409.2 → XP_005167466.1 integrin alpha-6 isoform X1

UniProtKB/TrEMBL

A0A8M2BER2, A8WHQ8, E7F087

Related

ENSDARP00000098022.3, ENSDART00000114168.5

Conserved Domains (2) summary

smart00191
Location:378 → 431

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:476 → 939

Integrin_alpha2; Integrin alpha
XM_005167411.4 → XP_005167468.1 integrin alpha-6 isoform X2

UniProtKB/TrEMBL

A0A8M2BFG1, A8WHQ7

Related

ENSDARP00000076590.5, ENSDART00000082153.6

Conserved Domains (2) summary

smart00191
Location:378 → 431

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:476 → 939

Integrin_alpha2; Integrin alpha

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001144781.1: Suppressed sequence

Description

NM_001144781.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.