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Gspt2 G1 to S phase transition 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501582, updated on 3-Apr-2024

Summary

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Official Symbol
Gspt2provided by RGD
Official Full Name
G1 to S phase transition 2provided by RGD
Primary source
RGD:1563213
See related
Ensembl:ENSRNOG00000048817 AllianceGenome:RGD:1563213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563213
Summary
Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in cytoplasmic translational termination. Predicted to be located in cytosol. Predicted to be part of translation release factor complex. Orthologous to human GSPT2 (G1 to S phase transition 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
Xq22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (63582649..63597467)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (59587237..59589758)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (63959131..63961652, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2, pseudogene 1 Neighboring gene zinc finger, X-linked, duplicated B Neighboring gene zinc finger, X-linked, duplicated A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables translation release factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation release factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic peptide chain release factor GTP-binding subunit ERF3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109319.1 → NP_001102789.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3B

    See identical proteins and their annotated locations for NP_001102789.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473966
    UniProtKB/TrEMBL
    A0A096MJE3, A6IQ16
    Related
    ENSRNOP00000068098.1, ENSRNOT00000071762.3
    Conserved Domains (5) summary
    cd01883
    Location:209 → 425
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:205 → 629
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:54 → 71
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:434 → 514
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:521 → 627
    eRF3_C_III; C-terminal domain of eRF3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    63582649..63597467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280251.1 → XP_063136321.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3B isoform X1

    UniProtKB/TrEMBL
    A0A096MJE3, A6IQ16

  2. XM_063280252.1 → XP_063136322.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3B isoform X1

    UniProtKB/TrEMBL
    A0A096MJE3, A6IQ16

  3. XM_063280250.1 → XP_063136320.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3B isoform X1

    UniProtKB/TrEMBL
    A0A096MJE3, A6IQ16
Nucleotide Protein Strain
Heading Accession and Version

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