Gpr55 G protein-coupled receptor 55 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr55provided by RGD
Official Full Name: G protein-coupled receptor 55provided by RGD
Primary source: RGD:1559828
See related: Ensembl:ENSRNOG00000017521 AllianceGenome:RGD:1559828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cannabinoid receptor activity. Predicted to be involved in several processes, including activation of phospholipase C activity; bone resorption; and positive regulation of intracellular signal transduction. Predicted to be integral component of plasma membrane. Orthologous to human GPR55 (G protein-coupled receptor 55). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 49.8), Testes (RPKM 18.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (94037748..94081426, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (86584906..86640601, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (92961431..93011157, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice.
Title: GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice.
GPR55 activation prevents amphetamine-induced conditioned place preference and decrease the amphetamine-stimulated inflammatory response in the ventral hippocampus in male rats.
Title: GPR55 activation prevents amphetamine-induced conditioned place preference and decrease the amphetamine-stimulated inflammatory response in the ventral hippocampus in male rats.
Presynaptic nigral GPR55 receptors stimulate [(3) H]-GABA release through [(3) H]-cAMP production and PKA activation and promote motor behavior.
Title: Presynaptic nigral GPR55 receptors stimulate [(3) H]-GABA release through [(3) H]-cAMP production and PKA activation and promote motor behavior.
Contribution of G Protein-Coupled Receptor 55 to Periaqueductal Gray-Mediated Antinociception in the Inflammatory Pain.
Title: Contribution of G Protein-Coupled Receptor 55 to Periaqueductal Gray-Mediated Antinociception in the Inflammatory Pain.
The effect of intra-striatal administration of GPR55 agonist (LPI) and antagonist (ML193) on sensorimotor and motor functions in a Parkinson's disease rat model.
Title: The effect of intra-striatal administration of GPR55 agonist (LPI) and antagonist (ML193) on sensorimotor and motor functions in a Parkinson's disease rat model.
Lysophosphatidylinositol, an Endogenous Ligand for G Protein-Coupled Receptor 55, Has Anti-inflammatory Effects in Cultured Microglia.
Title: Lysophosphatidylinositol, an Endogenous Ligand for G Protein-Coupled Receptor 55, Has Anti-inflammatory Effects in Cultured Microglia.
Stimulation of atypical cannabinoid receptor GPR55 abolishes the symptoms of detrusor overactivity in spontaneously hypertensive rats.
Title: Stimulation of atypical cannabinoid receptor GPR55 abolishes the symptoms of detrusor overactivity in spontaneously hypertensive rats.
A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors.
Title: A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors.
Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
Title: Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
These results strongly suggest a role of GPR55 in procedural memory and constitute the first evidence indicating that this receptor regulates cognitive processes
Title: Blockade of GPR55 in the dorsolateral striatum impairs performance of rats in a T-maze paradigm.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cannabinoid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cannabinoid receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone resorption	ISO Inferred from Sequence Orthology more info
involved_in cannabinoid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled receptor 55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.