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Mknk1 MAPK interacting serine/threonine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500526, updated on 11-Apr-2024

Summary

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Official Symbol
Mknk1provided by RGD
Official Full Name
MAPK interacting serine/threonine kinase 1provided by RGD
Primary source
RGD:1559603
See related
Ensembl:ENSRNOG00000010381 AllianceGenome:RGD:1559603
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and regulation of translational initiation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 76.3), Adrenal (RPKM 75.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q35
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134554881..134594392)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129318128..129357641)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134691852..134730887)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene MOB kinase activator 3C Neighboring gene kinocilin Neighboring gene transmembrane protein 275

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: regulation by the Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways. Origanti S, et al. Cancer Res, 2007 May 15. PMID 17510413
  2. MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines. Chrestensen CA, et al. J Biol Chem, 2007 Feb 16. PMID 17130135
  3. Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. Chen S, et al. J Cereb Blood Flow Metab, 2007 May. PMID 16955078
  4. Molecules in focus: cytosolic phospholipase A2-alpha. Niknami M, et al. Int J Biochem Cell Biol, 2009 May. PMID 18761105
  5. Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis. Chrestensen CA, et al. Genes Cells, 2007 Oct. PMID 17903173

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112775

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salt stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 1
Names
MAP kinase signal-integrating kinase 1
MAP kinase-interacting serine/threonine kinase 1
MAPK signal-integrating kinase 1
mnk1
NP_001037732.1
XP_006238756.1
XP_006238758.1
XP_006238759.1
XP_006238760.1
XP_038966512.1
XP_038966513.1
XP_038966514.1
XP_038966515.1
XP_063144306.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044267.1 → NP_001037732.1  MAP kinase-interacting serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_001037732.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098754
    UniProtKB/Swiss-Prot
    Q4G050
    UniProtKB/TrEMBL
    A0A8L2QVH8, A6JZ51
    Conserved Domains (1) summary
    cd14174
    Location:34 → 322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    134554881..134594392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238697.4 → XP_006238759.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_006238759.1

    UniProtKB/TrEMBL
    A0A0G2K3K7, A0A8L2QVH8
    Related
    ENSRNOP00000072679.1, ENSRNOT00000091543.2
    Conserved Domains (2) summary
    smart00220
    Location:47 → 327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:40 → 328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  2. XM_063288236.1 → XP_063144306.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8

  3. XM_006238696.5 → XP_006238758.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_006238758.1

    UniProtKB/TrEMBL
    A0A0G2K3K7, A0A8L2QVH8
    Conserved Domains (2) summary
    smart00220
    Location:47 → 327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:40 → 328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  4. XM_006238698.5 → XP_006238760.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

    See identical proteins and their annotated locations for XP_006238760.1

    UniProtKB/Swiss-Prot
    Q4G050
    UniProtKB/TrEMBL
    A0A8L2QVH8, A6JZ51
    Conserved Domains (1) summary
    cd14174
    Location:34 → 322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  5. XM_039110587.2 → XP_038966515.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:31 → 200
    PKc_like; Protein Kinases, catalytic domain

  6. XM_039110585.2 → XP_038966513.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8L2QVH8
    Conserved Domains (1) summary
    cd14174
    Location:40 → 328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  7. XM_039110586.1 → XP_038966514.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:40 → 209
    PKc_like; Protein Kinases, catalytic domain

  8. XM_039110584.1 → XP_038966512.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:40 → 209
    PKc_like; Protein Kinases, catalytic domain

  9. XM_006238694.5 → XP_006238756.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QVH8
    Conserved Domains (2) summary
    smart00220
    Location:74 → 354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:67 → 355
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G050.1 GenPept UniProtKB/Swiss-Prot:Q4G050

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