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Gprc5d G protein-coupled receptor, class C, group 5, member D [ Rattus norvegicus (Norway rat) ]

Gene ID: 500349, updated on 3-Apr-2024

Summary

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Official Symbol
Gprc5dprovided by RGD
Official Full Name
G protein-coupled receptor, class C, group 5, member Dprovided by RGD
Primary source
RGD:1563887
See related
Ensembl:ENSRNOG00000008439 AllianceGenome:RGD:1563887
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563887
Summary
Predicted to enable protein kinase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and activation of protein kinase activity. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in extracellular exosome; intracellular membrane-bounded organelle; and plasma membrane. Orthologous to human GPRC5D (G protein-coupled receptor class C group 5 member D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 4.3), Spleen (RPKM 1.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169674874..169686965, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167943523..167955616, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168872897..168884925, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 47 Neighboring gene G protein-coupled receptor, class C, group 5, member A Neighboring gene ribosomal protein S17, pseudogene 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene heme binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Bräuner-Osborne H, et al. Biochim Biophys Acta, 2001 Apr 16. PMID 11311935
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptor family C group 5 member D
Names
G protein-coupled receptor, family C, group 5, member D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109254.1 → NP_001102724.1  G-protein coupled receptor family C group 5 member D

    See identical proteins and their annotated locations for NP_001102724.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473964
    UniProtKB/TrEMBL
    A6IMF4, D4A7N4
    Related
    ENSRNOP00000011141.4, ENSRNOT00000011141.5
    Conserved Domains (1) summary
    pfam00003
    Location:61 → 264
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    169674874..169686965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286578.1 → XP_063142648.1  G-protein coupled receptor family C group 5 member D isoform X1

    UniProtKB/TrEMBL
    A6IMF4, D4A7N4

  2. XM_039108223.2 → XP_038964151.1  G-protein coupled receptor family C group 5 member D isoform X2

    UniProtKB/TrEMBL
    A6IMF5
    Conserved Domains (2) summary
    cd14964
    Location:21 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:21 → 267
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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