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Lpar5 lysophosphatidic acid receptor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500317, updated on 30-Mar-2024

Summary

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Official Symbol
Lpar5provided by RGD
Official Full Name
lysophosphatidic acid receptor 5provided by RGD
Primary source
RGD:1562580
See related
Ensembl:ENSRNOG00000021401 AllianceGenome:RGD:1562580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr92; RGD1562580
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in behavioral response to pain and positive regulation of CREB transcription factor activity. Predicted to be integral component of membrane. Orthologous to human LPAR5 (lysophosphatidic acid receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 19.5), Thymus (RPKM 5.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159556735..159570216)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157870493..157883979)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157581000..157596454)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554095 Neighboring gene inhibitor of growth family, member 4 Neighboring gene acrosin binding protein Neighboring gene transfer RNA proline (anticodon AGG) 37 Neighboring gene uncharacterized LOC120102389 Neighboring gene chromodomain helicase DNA binding protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Possible involvement of lysophosphatidic acid receptor-5 gene in the acquisition of growth advantage of rat tumor cells. Okabe K, et al. Mol Carcinog, 2011 Aug. PMID 21374735
  2. Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain. Lin ME, et al. J Biol Chem, 2012 May 18. PMID 22461625, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in behavioral response to pain IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within behavioral response to pain ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CREB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysophosphatidic acid receptor 5
Names
G protein-coupled receptor 92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399104.1 → NP_001386033.1  lysophosphatidic acid receptor 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159556735..159570216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763298.4 → XP_008761520.1  lysophosphatidic acid receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_008761520.1

    UniProtKB/TrEMBL
    A6ILR0, D4ADR1
    Related
    ENSRNOP00000038032.4
    Conserved Domains (2) summary
    cd14964
    Location:40 → 66
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:39 → 324
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_008763297.3 → XP_008761519.1  lysophosphatidic acid receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_008761519.1

    UniProtKB/TrEMBL
    A6ILR0, D4ADR1
    Conserved Domains (2) summary
    cd14964
    Location:40 → 66
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:39 → 324
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_006237389.4 → XP_006237451.1  lysophosphatidic acid receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006237451.1

    UniProtKB/TrEMBL
    A6ILR0, D4ADR1
    Conserved Domains (2) summary
    cd14964
    Location:40 → 66
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:39 → 324
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_039108810.2 → XP_038964738.1  lysophosphatidic acid receptor 5 isoform X1

    UniProtKB/TrEMBL
    A6ILR0, D4ADR1
    Conserved Domains (2) summary
    cd14964
    Location:40 → 66
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:39 → 324
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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