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Sf3b5 Splicing factor 3b subunit 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50007, updated on 10-May-2024

Summary

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Official Symbol
Sf3b5provided by FlyBase
Official Full Name
Splicing factor 3b subunit 5provided by FlyBase
Primary source
FLYBASE:FBgn0040534
Locus tag
Dmel_CG11985
See related
AllianceGenome:FB:FBgn0040534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11985; Dmel\CG11985; sf3b5; SF3B5
Summary
Involved in regulation of gene expression and spermatogenesis. Part of SAGA complex and U2 snRNP. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human SF3B5 (splicing factor 3b subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
85C2-85C2; 3-48 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9014972..9015341, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4840694..4841063, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Potassium channel modulatory factor 1 Neighboring gene uncharacterized protein Neighboring gene tango Neighboring gene antisense RNA:CR31429 Neighboring gene neuralized

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans. Wu H, et al. Proc Natl Acad Sci U S A, 2016 Apr 12. PMID 27035939, Free PMC Article
  2. What do the structures of GCN5-containing complexes teach us about their function? Helmlinger D, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32739556
  3. Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module. Cornelio-Parra DV, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32911111
  4. The Gcn5 complexes in Drosophila as a model for metazoa. Torres-Zelada EF, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32735945
  5. Defining gene networks controlling the maintenance and function of the differentiation niche by an in vivo systematic RNAi screen. Gao Y, et al. J Genet Genomics, 2019 Jan 20. PMID 30745214

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data support an independent function of SF3B5 in the transcription coactivator activity of the Spt-Ada-Gcn5 acetyltransferase that is separate from its role in splicing.
    Title: The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
splicing factor 3b subunit 5
Names
CG11985-PA
Sf3b5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9014972..9015341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143932.3 → NP_652189.1  splicing factor 3b subunit 5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652189.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHI4
    UniProtKB/TrEMBL
    A0A1B2AKC8, Q4QPR9
    Related
    FBpp0081484
    Conserved Domains (1) summary
    pfam07189
    Location:3 → 77
    SF3b10; Splicing factor 3B subunit 10 (SF3b10)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHI4.1 Q9VHI4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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