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Stam signal transducing adaptor molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 498798, updated on 5-Mar-2024

Summary

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Official Symbol
Stamprovided by RGD
Official Full Name
signal transducing adaptor moleculeprovided by RGD
Primary source
RGD:1564499
See related
Ensembl:ENSRNOG00000060817 AllianceGenome:RGD:1564499
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564499
Summary
Predicted to enable ubiquitin-like protein ligase binding activity. Predicted to be involved in positive regulation of exosomal secretion; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; and regulation of extracellular exosome assembly. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ESCRT-0 complex. Orthologous to human STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 159.5), Kidney (RPKM 156.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (82028779..82074717)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (77120235..77166173)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (81209795..81256111)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene transmembrane protein 236 Neighboring gene uncharacterized LOC134482611 Neighboring gene mannose receptor, C type 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1. Blackstone C, et al. Biochem Biophys Res Commun, 2003 May 30. PMID 12745081
  2. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. Colombo M, et al. J Cell Sci, 2013 Dec 15. PMID 24105262
  3. The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Holleman J, et al. Mol Biol Cell, 2014 Jun 15. PMID 24790097, Free PMC Article
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of extracellular exosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ESCRT-0 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT-0 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal transducing adapter molecule 1
Names
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109121.2 → NP_001102591.1  signal transducing adapter molecule 1

    See identical proteins and their annotated locations for NP_001102591.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168933
    UniProtKB/TrEMBL
    A0A0G2JTT5, A0A0G2K9W6, B5DF55
    Related
    ENSRNOP00000075157.1, ENSRNOT00000077368.2
    Conserved Domains (3) summary
    cd11964
    Location:213 → 267
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    cd03568
    Location:9 → 142
    VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
    pfam03127
    Location:308 → 379
    GAT; GAT domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    82028779..82074717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600651.3 → XP_017456140.2  signal transducing adapter molecule 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTT5, A0A8I6A2K6
    Related
    ENSRNOP00000085119.1
    Conserved Domains (3) summary
    cd11964
    Location:211 → 265
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    cd17000
    Location:11 → 137
    VHS_STAM1; VHS (Vps27/Hrs/STAM) domain of Signal Transducing Adapter Molecule 1
    cd21389
    Location:301 → 377
    GAT_STAM1; non-canonical GAT domain found in signal transducing adapter molecule 1 (STAM-1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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