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Nrg3 neuregulin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498596, updated on 11-Apr-2024

Summary

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Symbol
Nrg3provided by RGD
Full Name
neuregulin 3provided by RGD
Primary source
RGD:1559678
See related
Ensembl:ENSRNOG00000063450 AllianceGenome:RGD:1559678
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559678
Summary
Predicted to enable chemorepellent activity. Predicted to be involved in modulation of chemical synaptic transmission. Predicted to act upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Predicted to be integral component of membrane. Predicted to be active in glutamatergic synapse. Orthologous to human NRG3 (neuregulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 66.6) and Brain (RPKM 50.7) See more
Orthologs
human mouse all
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Genomic context

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Location:
16p14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (14256540..15374107, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (14229270..15352505, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (15763031..16932208, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene elongin A, pseudogene 1 Neighboring gene elongin-A2-like 1 Neighboring gene uncharacterized LOC134482458 Neighboring gene uncharacterized LOC134482324 Neighboring gene uncharacterized LOC134482459 Neighboring gene uncharacterized LOC108348383 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase like 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Developmental expression of Neuregulin-3 in the rat central nervous system. Rahman A, et al. J Comp Neurol, 2019 Mar 1. PMID 30328115
  2. Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition. Zhou L, et al. Neuropsychopharmacology, 2018 May. PMID 29114105, Free PMC Article
  3. The characterization of a mouse mutant that displays abnormal mammary gland development. Howard BA, et al. Mamm Genome, 2000 Mar. PMID 10723730
  4. Neuregulins and cancer. Montero JC, et al. Clin Cancer Res, 2008 Jun 1. PMID 18519747
  5. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Zhang D, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275162, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chemorepellent activity ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERBB4-ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mammary gland development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mammary placode formation ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pattern specification process ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pro-neuregulin-3, membrane-bound isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    14256540..15374107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275921.1 → XP_063131991.1  pro-neuregulin-3, membrane-bound isoform isoform X9

  2. XM_039095029.2 → XP_038950957.1  pro-neuregulin-3, membrane-bound isoform isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y1H8
    Conserved Domains (1) summary
    PHA02887
    Location:285 → 338
    PHA02887; EGF-like protein; Provisional

  3. XM_039095033.2 → XP_038950961.1  pro-neuregulin-3, membrane-bound isoform isoform X8

    UniProtKB/TrEMBL
    A0A8I5Y1H8
    Conserved Domains (1) summary
    PHA02887
    Location:285 → 338
    PHA02887; EGF-like protein; Provisional

  4. XM_039095032.2 → XP_038950960.1  pro-neuregulin-3, membrane-bound isoform isoform X7

    UniProtKB/TrEMBL
    A0A8I5Y1H8
    Conserved Domains (1) summary
    PHA02887
    Location:285 → 338
    PHA02887; EGF-like protein; Provisional

  5. XM_039095028.2 → XP_038950956.1  pro-neuregulin-3, membrane-bound isoform isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y1H8
    Conserved Domains (1) summary
    PHA02887
    Location:285 → 338
    PHA02887; EGF-like protein; Provisional

  6. XM_039095031.2 → XP_038950959.1  pro-neuregulin-3, membrane-bound isoform isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y1H8
    Conserved Domains (1) summary
    PHA02887
    Location:285 → 338
    PHA02887; EGF-like protein; Provisional

  7. XM_039095027.2 → XP_038950955.1  pro-neuregulin-3, membrane-bound isoform isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y1H8
    Related
    ENSRNOP00000077709.1
    Conserved Domains (1) summary
    PHA02887
    Location:285 → 338
    PHA02887; EGF-like protein; Provisional

  8. XM_039095030.2 → XP_038950958.1  pro-neuregulin-3, membrane-bound isoform isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y1H8, A0A8I5ZU04
    Related
    ENSRNOP00000080898.1
    Conserved Domains (1) summary
    PHA02887
    Location:285 → 338
    PHA02887; EGF-like protein; Provisional

  9. XM_017600398.3 → XP_017455887.2  pro-neuregulin-3, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y1H8
    Conserved Domains (1) summary
    PHA02887
    Location:285 → 338
    PHA02887; EGF-like protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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