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Akap11 A-kinase anchoring protein 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498549, updated on 30-Mar-2024

Summary

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Official Symbol
Akap11provided by RGD
Official Full Name
A-kinase anchoring protein 11provided by RGD
Primary source
RGD:2079
See related
Ensembl:ENSRNOG00000009987 AllianceGenome:RGD:2079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akap
Summary
Enables kinase regulator activity; protein kinase A binding activity; and protein phosphatase 1 binding activity. Involved in positive regulation of establishment of endothelial barrier and positive regulation of protein phosphorylation. Located in peroxisome. Part of protein-containing complex. Orthologous to human AKAP11 (A-kinase anchoring protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 410.4), Kidney (RPKM 202.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (60320839..60365480, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (53911635..53956138, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (60722138..60766673, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 11 Neighboring gene uncharacterized LOC102549816 Neighboring gene uncharacterized LOC120097049 Neighboring gene diacylglycerol kinase, eta Neighboring gene uncharacterized LOC108353040

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis. Garnis C, et al. Int J Cancer, 2005 Sep 20. PMID 15849745
  2. AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts. Okutsu R, et al. Kidney Int, 2008 Dec. PMID 19008911
  3. GABAC-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. Yang L, et al. J Pharmacol Sci, 2008 Apr. PMID 18385542
  4. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. Lester LB, et al. J Biol Chem, 1996 Apr 19. PMID 8621616
  5. PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. Radeva MY, et al. PLoS One, 2014. PMID 25188285, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest that GABA(C)-receptor rho subunit stimulation activates PKA via A-kinase anchoring protein 220 (AKAP 220).
    Title: GABAC-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A catalytic subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase A regulatory subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endosome IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization to endosome ISO
Inferred from Sequence Orthology
more info
  
involved_in renal water homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within renal water homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
A-kinase anchor protein 11
Names
A kinase (PRKA) anchor protein 11
A-kinase anchor protein 220 kDa
A-kinase anchoring protein 220, AKAP 220
AKAP 220
AKAP-11
PRKA11
protein kinase A-anchoring protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394793.1 → NP_001381722.1  A-kinase anchor protein 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6HTX6, D3ZS99
    Conserved Domains (1) summary
    cl14906
    Location:1778 → 1879
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    60320839..60365480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274564.1 → XP_063130634.1  A-kinase anchor protein 11 isoform X1

  2. XM_063274565.1 → XP_063130635.1  A-kinase anchor protein 11 isoform X1

  3. XM_039093595.2 → XP_038949523.1  A-kinase anchor protein 11 isoform X1

    UniProtKB/TrEMBL
    A6HTX6, D3ZS99
    Related
    ENSRNOP00000054952.3
    Conserved Domains (1) summary
    cl14906
    Location:1779 → 1880
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

  4. XM_017599779.2 → XP_017455268.1  A-kinase anchor protein 11 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JZI9

  5. XM_063274563.1 → XP_063130633.1  A-kinase anchor protein 11 isoform X2

  6. XM_063274562.1 → XP_063130632.1  A-kinase anchor protein 11 isoform X1

  7. XM_039093596.2 → XP_038949524.1  A-kinase anchor protein 11 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GLR8
    Related
    ENSRNOP00000096795.1

  8. XM_017599780.3 → XP_017455269.1  A-kinase anchor protein 11 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GLR8

  9. XM_063274566.1 → XP_063130636.1  A-kinase anchor protein 11 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012773.2: Suppressed sequence

    Description
    NM_012773.2: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62924.1 GenPept UniProtKB/Swiss-Prot:Q62924

Gene LinkOut

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