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Grb10 growth factor receptor bound protein 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498416, updated on 13-Apr-2024

Summary

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Official Symbol
Grb10provided by RGD
Official Full Name
growth factor receptor bound protein 10provided by RGD
Primary source
RGD:1566234
See related
Ensembl:ENSRNOG00000004290 AllianceGenome:RGD:1566234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566234
Summary
Enables insulin receptor binding activity. Involved in insulin receptor signaling pathway; negative regulation of glycogen biosynthetic process; and positive regulation of phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 551.4), Adrenal (RPKM 499.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14q21
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (90708653..90816399, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (86495051..86602800, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (92021851..92122249, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096666 Neighboring gene fidgetin-like 1 Neighboring gene dopa decarboxylase Neighboring gene uncharacterized LOC120096667 Neighboring gene uncharacterized LOC102552764 Neighboring gene uncharacterized LOC134481784

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Growth factor receptor-bound protein 10-mediated negative regulation of the insulin-like growth factor-1 receptor-activated signalling pathway results in cognitive disorder in diabetic rats. Ma L, et al. J Neuroendocrinol, 2013 Jul. PMID 23614367
  2. MiR199a is implicated in embryo implantation by regulating Grb10 in rat. Xia HF, et al. Reproduction, 2014 Jan. PMID 24149516
  3. Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway. Mounier C, et al. Mol Cell Endocrinol, 2001 Feb 28. PMID 11223174
  4. Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Liu M, et al. Cell Metab, 2014 Jun 3. PMID 24746805, Free PMC Article
  5. Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Depetris RS, et al. Nat Struct Mol Biol, 2009 Aug. PMID 19648926, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In rat uterus, enforced miR199a expression suppresses cell proliferation partially through targeting Grb10.
    Title: MiR199a is implicated in embryo implantation by regulating Grb10 in rat.
  2. findings indicate that endogenous overexpression of Grb10 functions as a suppressor of the IGF1-IR pathway, which may represent an important mechanism for regulating cognitive disorder in diabetes
    Title: Growth factor receptor-bound protein 10-mediated negative regulation of the insulin-like growth factor-1 receptor-activated signalling pathway results in cognitive disorder in diabetic rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor complex adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor complex adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_negative_effect ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_negative_effect gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of glucose import IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to insulin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vascular associated smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
growth factor receptor-bound protein 10
Names
GRB10 adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401403.1 → NP_001388332.1  growth factor receptor-bound protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    P0CE43

  2. NM_001401404.1 → NP_001388333.1  growth factor receptor-bound protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2JYJ1
    Related
    ENSRNOP00000070674.1, ENSRNOT00000085175.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    90708653..90816399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273491.1 → XP_063129561.1  growth factor receptor-bound protein 10 isoform X8

  2. XM_063273489.1 → XP_063129559.1  growth factor receptor-bound protein 10 isoform X6

  3. XM_063273488.1 → XP_063129558.1  growth factor receptor-bound protein 10 isoform X5

    UniProtKB/Swiss-Prot
    P0CE43

  4. XM_063273487.1 → XP_063129557.1  growth factor receptor-bound protein 10 isoform X5

    UniProtKB/Swiss-Prot
    P0CE43

  5. XM_063273492.1 → XP_063129562.1  growth factor receptor-bound protein 10 isoform X8

  6. XM_063273486.1 → XP_063129556.1  growth factor receptor-bound protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JYJ1

  7. XM_039092313.2 → XP_038948241.1  growth factor receptor-bound protein 10 isoform X3

    Conserved Domains (4) summary
    cd10415
    Location:529 → 636
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:328 → 450
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:208 → 299
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:468 → 509
    BPS; BPS (Between PH and SH2)

  8. XM_063273490.1 → XP_063129560.1  growth factor receptor-bound protein 10 isoform X7

  9. XM_039092307.2 → XP_038948235.1  growth factor receptor-bound protein 10 isoform X1

    Conserved Domains (4) summary
    cd10415
    Location:584 → 691
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:383 → 505
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:266 → 354
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:523 → 564
    BPS; BPS (Between PH and SH2)

  10. XM_039092311.2 → XP_038948239.1  growth factor receptor-bound protein 10 isoform X2

    UniProtKB/TrEMBL
    A0A9M1XG80
    Related
    ENSRNOP00000048487.4
    Conserved Domains (4) summary
    cd10415
    Location:529 → 636
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:328 → 450
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:211 → 299
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:468 → 509
    BPS; BPS (Between PH and SH2)

  11. XM_039092308.2 → XP_038948236.1  growth factor receptor-bound protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JYJ1
    Conserved Domains (4) summary
    cd10415
    Location:529 → 636
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:328 → 450
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:211 → 299
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:468 → 509
    BPS; BPS (Between PH and SH2)

  12. XM_039092309.2 → XP_038948237.1  growth factor receptor-bound protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JYJ1
    Conserved Domains (4) summary
    cd10415
    Location:529 → 636
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:328 → 450
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:211 → 299
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:468 → 509
    BPS; BPS (Between PH and SH2)

  13. XM_039092315.2 → XP_038948243.1  growth factor receptor-bound protein 10 isoform X5

    UniProtKB/Swiss-Prot
    P0CE43
    Conserved Domains (4) summary
    cd10415
    Location:492 → 599
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:291 → 413
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:174 → 262
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:431 → 472
    BPS; BPS (Between PH and SH2)

  14. XM_039092316.2 → XP_038948244.1  growth factor receptor-bound protein 10 isoform X5

    UniProtKB/Swiss-Prot
    P0CE43
    Conserved Domains (4) summary
    cd10415
    Location:492 → 599
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:291 → 413
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:174 → 262
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:431 → 472
    BPS; BPS (Between PH and SH2)

  15. XM_039092310.2 → XP_038948238.1  growth factor receptor-bound protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JYJ1
    Conserved Domains (4) summary
    cd10415
    Location:529 → 636
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:328 → 450
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:211 → 299
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:468 → 509
    BPS; BPS (Between PH and SH2)

  16. XM_039092317.2 → XP_038948245.1  growth factor receptor-bound protein 10 isoform X5

    UniProtKB/Swiss-Prot
    P0CE43
    Conserved Domains (4) summary
    cd10415
    Location:492 → 599
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:291 → 413
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:174 → 262
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:431 → 472
    BPS; BPS (Between PH and SH2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001109093.1: Suppressed sequence

    Description
    NM_001109093.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CE43.1 GenPept UniProtKB/Swiss-Prot:P0CE43

Gene LinkOut

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