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eIF4H1 eukaryotic translation initiation factor 4H1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49809, updated on 27-Mar-2024

Summary

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Official Symbol
eIF4H1provided by FlyBase
Official Full Name
eukaryotic translation initiation factor 4H1provided by FlyBase
Primary source
FLYBASE:FBgn0262734
Locus tag
Dmel_CG4429
See related
AllianceGenome:FB:FBgn0262734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe1B9; cg4429; CG4429; Dmel\CG4429; eIF4H; EIF4H1; MRE9; Rbp2; RNA-binding protein 2; rrm2; RRM2
Summary
Predicted to enable RNA binding activity and ribosomal small subunit binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Predicted to be located in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See eIF4H1 in Genome Data Viewer
Location:
14C6-14C8; 1-53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16448665..16454972)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16342698..16349005)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 subunit alpha Neighboring gene rings lost Neighboring gene uncharacterized protein Neighboring gene paralytic Neighboring gene Calnexin 14D Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence. McGurk L, et al. Hum Mol Genet, 2021 Sep 15. PMID 34077532, Free PMC Article
  2. Role for para sodium channel gene 3' UTR in the modification of Drosophila seizure susceptibility. Song J, et al. Dev Neurobiol, 2007 Dec. PMID 17918245
  3. Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures. Parker L, et al. Genetics, 2011 Feb. PMID 21115970, Free PMC Article
  4. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Goodman LD, et al. Acta Neuropathol Commun, 2019 Apr 25. PMID 31023341, Free PMC Article
  5. DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation. Linsalata AE, et al. EMBO Rep, 2019 Sep. PMID 31347257, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 4H1
Names
CG4429-PA
CG4429-PB
CG4429-PC
CG4429-PD
CG4429-PE
RNA-binding protein 2
anon-fast-evolving-1B9
eIF4H1-PA
eIF4H1-PB
eIF4H1-PC
eIF4H1-PD
eIF4H1-PE
mRNA-like ncRNA in embryogenesis 9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16448665..16454972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080220.5 → NP_524959.1  eukaryotic translation initiation factor 4H1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524959.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH88, Q9VXF8
    Related
    FBpp0074055
    Conserved Domains (3) summary
    COG0724
    Location:19 → 224
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam05091
    Location:173 → 235
    eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
    cl17169
    Location:28 → 106
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_167522.5 → NP_727982.1  eukaryotic translation initiation factor 4H1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH88, Q8IR13
    Related
    FBpp0074056
    Conserved Domains (3) summary
    COG0724
    Location:18 → 223
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam05091
    Location:172 → 234
    eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
    cl17169
    Location:27 → 105
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001298401.1 → NP_001285330.1  eukaryotic translation initiation factor 4H1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285330.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R50, X2JC79
    Conserved Domains (2) summary
    COG0724
    Location:19 → 139
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12401
    Location:28 → 106
    RRM_eIF4H; RNA recognition motif in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins

  4. NM_206764.3 → NP_996487.1  eukaryotic translation initiation factor 4H1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996487.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R50, Q7KUX7
    Conserved Domains (2) summary
    COG0724
    Location:19 → 139
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:28 → 106
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_001298402.1 → NP_001285331.1  eukaryotic translation initiation factor 4H1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285331.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH88, X2JE34
    Conserved Domains (3) summary
    COG0724
    Location:11 → 216
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam05091
    Location:165 → 227
    eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
    cl17169
    Location:20 → 98
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q26272 Q26272
Q7KUX7 Q7KUX7
Q8IR13 Q8IR13
Q9VXF8 Q9VXF8
X2JC79 X2JC79
X2JE34 X2JE34

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