tcf7 transcription factor 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tcf7provided by ZNC
Official Full Name: transcription factor 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-050222-4
See related: Ensembl:ENSDARG00000038672 AllianceGenome:ZFIN:ZDB-GENE-050222-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within pectoral fin development and spinal cord dorsal/ventral patterning. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Is expressed in several structures, including dermal bone; nervous system; optic cup; pectoral fin bud; and prechordal plate. Orthologous to human TCF7 (transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (45268118..45337037)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (45227307..45296226)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nanog safeguards early embryogenesis against global activation of maternal beta-catenin activity by interfering with TCF factors.
Title: Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.
C-terminal splice variants of correspond to human B, C, and D isoforms
Title: Expression pattern of zebrafish tcf7 suggests unexplored domains of Wnt/beta-catenin activity.

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General gene information

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Markers

Z6087 (e-PCR)
- UniSTS:41777

Z4082 (e-PCR)
- UniSTS:2890

G40693 (e-PCR)
- UniSTS:32358

z6087 (e-PCR), detects polymorphism
- UniSTS:238204

z8803 (e-PCR), detects polymorphism
- UniSTS:204973

GOF16 (e-PCR)
- UniSTS:204746

G47492 (e-PCR)
- UniSTS:108268

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	TAS Traceable Author Statement more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development	IEA Inferred from Electronic Annotation more info
involved_in epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pectoral fin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spinal cord dorsal/ventral patterning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor 7

Names: T-cell factor 7; transcription factor 7 (T-cell specific, HMG-box)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.