kitb KIT proto-oncogene, receptor tyrosine kinase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kitbprovided by ZNC
Official Full Name: KIT proto-oncogene, receptor tyrosine kinase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050916-2
See related: Ensembl:ENSDARG00000056133 AllianceGenome:ZFIN:ZDB-GENE-050916-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within embryonic hemopoiesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gonad; immune system; nervous system; otic vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (19473028..19502378, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (18780091..18809441, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

strong evidence for a Kit-mediated bi-directional communication system in the zebrafish ovarian follicle
Title: Spatial distribution and receptor specificity of zebrafish Kit system--evidence for a Kit-mediated bi-directional communication system in the preovulatory ovarian follicle.
The expression pattern of kita and kitb in zebrafish together approximates that of Kit in mouse.
Title: kitb, a second zebrafish ortholog of mouse Kit.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytokine binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Fc receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Fc receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Kit signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Kit signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic progenitor cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: KIT proto-oncogene, receptor tyrosine kinase b

Names: kit receptor b; type III tyrosine kinase; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b

NP_001137390.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143918.1 → NP_001137390.1 KIT proto-oncogene, receptor tyrosine kinase b precursor

Status: VALIDATED

Source sequence(s)

AY884202, BX548248, CU458998, DQ072166, EB931763

UniProtKB/TrEMBL

A0A8M1NPF4, B8A5K6

Related

ENSDARP00000044029.6, ENSDART00000044030.7

Conserved Domains (6) summary

smart00409
Location:225 → 305

IG; Immunoglobulin

smart00410
Location:121 → 201

IG_like; Immunoglobulin like

pfam07679
Location:319 → 406

I-set; Immunoglobulin I-set domain

pfam07714
Location:583 → 894

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:309 → 407

Ig; Immunoglobulin domain

cl21453
Location:547 → 896

PKc_like; Protein Kinases, catalytic domain