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Plcz1 phospholipase C, zeta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497197, updated on 13-Apr-2024

Summary

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Symbol
Plcz1provided by RGD
Full Name
phospholipase C, zeta 1provided by RGD
Primary source
RGD:1359567
See related
Ensembl:ENSRNOG00000008514 AllianceGenome:RGD:1359567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol phosphate binding activity and phosphatidylinositol phospholipase C activity. Involved in positive regulation of cytosolic calcium ion concentration involved in egg activation. Located in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 17. Orthologous to human PLCZ1 (phospholipase C zeta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 270.0) See more
Orthologs
human mouse all
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Genomic context

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See Plcz1 in Genome Data Viewer
Location:
4q44
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (174604281..174660368, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (172873110..172929191, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (174125072..174181524, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RERG like Neighboring gene uncharacterized LOC120102423 Neighboring gene phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma Neighboring gene capping actin protein of muscle Z-line subunit alpha 3 Neighboring gene uncharacterized LOC108350783

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ. Nomikos M, et al. Biochem J, 2017 Mar 7. PMID 28270562
  2. Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs. Kouchi Z, et al. J Biol Chem, 2004 Mar 12. PMID 14701816
  3. PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Saunders CM, et al. Development, 2002 Aug. PMID 12117804
  4. Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP. Escoffier J, et al. Hum Mol Genet, 2016 Mar 1. PMID 26721930, Free PMC Article
  5. Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish. Ito M, et al. Biol Reprod, 2008 Jun. PMID 18322275

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. All PLCZ1 proteins including fish could induce Ca(2+) oscillations in mouse eggs, but the activity was variable in the order of human >> mouse > medaka >> rat, estimated from minimal RNA concentration to induce Ca(2+) spikes.
    Title: Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within egg activation ISO
Inferred from Sequence Orthology
more info
  
involved_in egg activation ISO
Inferred from Sequence Orthology
more info
  
involved_in egg activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
NOT located_in pronucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pronucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sperm head ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Names
PLC-zeta-1
phosphoinositide phospholipase C-zeta-1
NP_001012234.1
XP_006237662.1
XP_017448260.1
XP_038963974.1
XP_038963975.1
XP_038963976.1
XP_038963978.1
XP_038963979.1
XP_038963980.1
XP_063142523.1
XP_063142524.1
XP_063142525.1
XP_063142526.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012234.2 → NP_001012234.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

    See identical proteins and their annotated locations for NP_001012234.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5FX52
    UniProtKB/TrEMBL
    A6IMM6
    Related
    ENSRNOP00000011376.4, ENSRNOT00000011376.5
    Conserved Domains (2) summary
    PLN02952
    Location:78 → 640
    PLN02952; phosphoinositide phospholipase C
    cl14615
    Location:161 → 488
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    174604281..174660368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286453.1 → XP_063142523.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q5FX52
    UniProtKB/TrEMBL
    A6IMM6

  2. XM_063286454.1 → XP_063142524.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q5FX52
    UniProtKB/TrEMBL
    A6IMM6

  3. XM_063286456.1 → XP_063142526.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

  4. XM_039108048.2 → XP_038963976.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    Conserved Domains (2) summary
    PLN02230
    Location:1 → 529
    PLN02230; phosphoinositide phospholipase C 4
    cl14615
    Location:52 → 379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  5. XM_039108050.2 → XP_038963978.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    Conserved Domains (2) summary
    PLN02230
    Location:1 → 529
    PLN02230; phosphoinositide phospholipase C 4
    cl14615
    Location:52 → 379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  6. XM_006237600.5 → XP_006237662.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

    Conserved Domains (4) summary
    cd00275
    Location:494 → 619
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02952
    Location:54 → 616
    PLN02952; phosphoinositide phospholipase C
    pfam09279
    Location:55 → 137
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:137 → 464
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  7. XM_039108047.2 → XP_038963975.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    Conserved Domains (2) summary
    PLN02230
    Location:1 → 529
    PLN02230; phosphoinositide phospholipase C 4
    cl14615
    Location:52 → 379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  8. XM_063286455.1 → XP_063142525.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

  9. XM_039108051.2 → XP_038963979.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

    Conserved Domains (2) summary
    PLN02952
    Location:23 → 417
    PLN02952; phosphoinositide phospholipase C
    cl14615
    Location:23 → 265
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  10. XM_039108046.2 → XP_038963974.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    Conserved Domains (2) summary
    PLN02230
    Location:1 → 529
    PLN02230; phosphoinositide phospholipase C 4
    cl14615
    Location:52 → 379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  11. XM_017592771.3 → XP_017448260.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

    Conserved Domains (4) summary
    cd00275
    Location:494 → 619
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02952
    Location:54 → 616
    PLN02952; phosphoinositide phospholipase C
    pfam09279
    Location:55 → 137
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:137 → 464
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  12. XM_039108052.2 → XP_038963980.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5

    Conserved Domains (2) summary
    cd00275
    Location:252 → 377
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:1 → 222
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RNA

  1. XR_010065686.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FX52.1 GenPept UniProtKB/Swiss-Prot:Q5FX52

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