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fgfrl1b fibroblast growth factor receptor like 1b [ Danio rerio (zebrafish) ]

Gene ID: 497135, updated on 27-Mar-2024

Summary

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Official Symbol
fgfrl1bprovided by ZNC
Official Full Name
fibroblast growth factor receptor like 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050201-3
See related
Ensembl:ENSDARG00000052556 AllianceGenome:ZFIN:ZDB-GENE-050201-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7154242
Summary
Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Acts upstream of or within cartilage development. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; endoderm; mesoderm; nervous system; and vasculature. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 14
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (41600339..41678813, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (41233106..41311602, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene novel immune-type receptor 14b Neighboring gene novel immune-type receptor 13 Neighboring gene solute carrier family 7 member 11 Neighboring gene uncharacterized LOC103908766

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evidence for a transposition event in a second NITR gene cluster in zebrafish. Yoder JA, et al. Immunogenetics, 2008 May. PMID 18330557, Free PMC Article
  2. Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor. Trueb B, et al. Biochim Biophys Acta, 2005 Jan 21. PMID 15652159
  3. Swimming-induced exercise promotes hypertrophy and vascularization of fast skeletal muscle fibres and activation of myogenic and angiogenic transcriptional programs in adult zebrafish. Palstra AP, et al. BMC Genomics, 2014 Dec 18. PMID 25518849, Free PMC Article
  4. Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. Trueb B, et al. J Biol Chem, 2003 Sep 5. PMID 12813049
  5. An essential role for zebrafish Fgfrl1 during gill cartilage development. Hall C, et al. Mech Dev, 2006 Dec. PMID 17011755

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fibroblast growth factor receptor-like 1b
Names
FGF receptor-like protein 1b beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012263.2 → NP_001012263.2  fibroblast growth factor receptor-like 1b precursor

    See identical proteins and their annotated locations for NP_001012263.2

    Status: PROVISIONAL

    Source sequence(s)
    AJ781309
    UniProtKB/TrEMBL
    A0A8M1N444, Q5K373
    Related
    ENSDARP00000152965.1, ENSDART00000185925.1
    Conserved Domains (5) summary
    cd05856
    Location:158 → 237
    Ig2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)
    smart00408
    Location:43 → 103
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:165 → 237
    IG_like; Immunoglobulin like
    pfam07679
    Location:26 → 113
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:260 → 355
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    41600339..41678813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173306.4 → XP_005173363.1  fibroblast growth factor receptor-like 1b isoform X1

    See identical proteins and their annotated locations for XP_005173363.1

    UniProtKB/TrEMBL
    A0A8M1N444, Q5K373
    Related
    ENSDARP00000139055.1, ENSDART00000163039.3
    Conserved Domains (5) summary
    cd05856
    Location:158 → 237
    Ig2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)
    smart00408
    Location:43 → 103
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:165 → 237
    IG_like; Immunoglobulin like
    pfam07679
    Location:26 → 113
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:260 → 355
    Ig; Immunoglobulin domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394928.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    69612..153868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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