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tab2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 494163, updated on 27-Mar-2024

Summary

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Official Symbol
tab2provided by ZNC
Official Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-933
See related
Ensembl:ENSDARG00000021509 AllianceGenome:ZFIN:ZDB-GENE-040426-933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
map3k7ip2; zgc:77446
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Involved in heart development. Acts upstream of or within chordate embryonic development and convergent extension involved in gastrulation. Is expressed in bulbus arteriosus; dorsal aorta; and posterior cardinal vein. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tab2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (1329508..1350296)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (1308522..1329345)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene nucleoporin 43 Neighboring gene scavenger receptor class A, member 5 (putative) Neighboring gene metabolism of cobalamin associated C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. TAK1-binding proteins (TAB1 and TAB2) in grass carp (Ctenopharyngodon idella): identification, characterization, and expression analysis after infection with Ichthyophthirius multifiliis. Zhao F, et al. Fish Shellfish Immunol, 2014 Jun. PMID 24747054
  2. Haploinsufficiency of TAB2 causes congenital heart defects in humans. Thienpont B, et al. Am J Hum Genet, 2010 Jun 11. PMID 20493459, Free PMC Article
  3. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
  4. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein C, et al. Genome Biol, 2007. PMID 18039395, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within convergent extension involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Names
TGF-beta-activated kinase 1-binding protein 2
mitogen-activated protein kinase kinase kinase 7 interacting protein 2
mitogen-activated protein kinase kinase kinase 7-interacting protein 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316693.1 → NP_001303622.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    BC065982, CK126241, CR536610
    UniProtKB/Swiss-Prot
    Q5RFW2, Q6NZS9
    Related
    ENSDARP00000019647.4, ENSDART00000017791.7
    Conserved Domains (3) summary
    smart00547
    Location:685 → 708
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:686 → 705
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    1329508..1350296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352472.2 → XP_017207961.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z392

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009900.1: Suppressed sequence

    Description
    NM_001009900.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RFW2.1 GenPept UniProtKB/Swiss-Prot:Q5RFW2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.