CYP1A2 cytochrome P450 family 1 subfamily A member 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CYP1A2provided by VGNC
Official Full Name: cytochrome P450 family 1 subfamily A member 2provided by VGNC
Primary source: VGNC:VGNC:50333
See related: Ensembl:ENSCAFG00845017565
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: DAH2; CYPIA2
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Genomic context

Location:: chromosome: 30

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	30	NC_051834.1 (38023809..38029593)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	30	NC_006612.4 (37751388..37757086)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	30	NC_049251.1 (38258389..38264108)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	30	NC_049290.1 (37976275..37981991)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	30	NC_049771.1 (38002364..38008076)

Chromosome 30 - NC_051834.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that CYP1A2 is significant enzyme responsible for formation of acetaminophen from phenacetin; however, it is not likely to be only enzyme or pathway responsible for the elimination of phenacetin or in vivo generation of acetaminophen.
Title: Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs.
a total of 508 dogs from 38 different breeds were genotyped for the CYP1A2 1117C > T polymorphism
Title: Detection of the CYP1A2 1117C>T polymorphism in 14 dog breeds.
A single nucleotide polymorphism in the dog CYP1A2 gene causes these animals to be CYP1A2 deficient (i.e., lack functional CYP1A2 enzyme activity). Genotyping a colony of 79 dogs revealed 77% wild-type, 19% heterozygous, and 4% homozygous mutant animals
Title: Frequency of CYP1A2 polymorphism in beagle dogs.
There is the interindividual variability between the pharmacokinetic profiles of the YM-64227 with respect to the CYP1A2 deficiency polymorphism.
Title: Elucidation of the effects of the CYP1A2 deficiency polymorphism in the metabolism of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1h)-one (YM-64227), a phosphodiesterase type 4 inhibitor, and its metabolites in dogs.
canine CYP1A2 1117 C > T SNP causes protein deletion
Title: Identification of the novel canine CYP1A2 1117 C > T SNP causing protein deletion.

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General gene information

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Markers

CYP1A1 (e-PCR), detects polymorphism
- UniSTS:266200

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 17-alpha-hydroxyprogesterone aldolase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info	PubMed
enables steroid 17-alpha-monooxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hormone biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in progesterone metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cytochrome P450 1A2

Names: Cholesterol 25-hydroxylase; Cytochrome P450-D2; Cytochrome-P450-1A2; cytochrome P450, family 1, subfamily A, polypeptide 2; hydroperoxy icosatetraenoate dehydratase

NP_001008720.1

EC 1.14.14.1

EC 4.2.1.152

XP_038297673.1

EC 1.14.14.1

EC 4.2.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008720.1 → NP_001008720.1 cytochrome P450 1A2

See identical proteins and their annotated locations for NP_001008720.1

Status: PROVISIONAL

Source sequence(s)

AB094347

UniProtKB/TrEMBL

Q5R2U1, Q5R2U2

Related

ENSCAFP00845024423.1, ENSCAFT00845031200.1

Conserved Domains (1) summary

pfam00067
Location:38 → 490

p450; Cytochrome P450

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051834.1 Reference ROS_Cfam_1.0

Range

38023809..38029593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038441745.1 → XP_038297673.1 cytochrome P450 1A2 isoform X1

UniProtKB/TrEMBL

A0A8C0MW85, A0A8I3P112

Conserved Domains (1) summary

cl41757
Location:68 → 502

cytochrome_P450; cytochrome P450 (CYP) superfamily