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CYP19A1 cytochrome P450 family 19 subfamily A member 1 [ Canis lupus familiaris (dog) ]

Gene ID: 494003, updated on 5-Mar-2024

Summary

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Official Symbol
CYP19A1provided by VGNC
Official Full Name
cytochrome P450 family 19 subfamily A member 1provided by VGNC
Primary source
VGNC:VGNC:50331
See related
Ensembl:ENSCAFG00845024965
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
CYP19
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 30
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (17098681..17221672, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (16883348..16914898, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (17248285..17280035, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (17024100..17055822, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (17141587..17173348, complement)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119866890 Neighboring gene adaptor related protein complex 4 subunit epsilon 1 Neighboring gene TNF alpha induced protein 8 like 3 Neighboring gene uncharacterized LOC119866891 Neighboring gene uncharacterized LOC111093373 Neighboring gene gliomedin Neighboring gene uncharacterized LOC102156824 Neighboring gene Dmx like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Profile of Steroid Receptors and Increased Aromatase Immunoexpression in Canine Inflammatory Mammary Cancer as a Potential Therapeutic Target. De Andrés PJ, et al. Reprod Domest Anim, 2016 Apr. PMID 26899138
  2. Cytochrome P450 aromatase expression in canine nervous tissue: an immunohistochemical study. Karahan S, et al. Pol J Vet Sci, 2008. PMID 19227133
  3. Altered expression of CYP17A1 and CYP19A1 in undescended testes of dogs with unilateral cryptorchidism. Krzeminska P, et al. Anim Genet, 2020 Oct. PMID 32657440

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Altered expression of CYP17A1 and CYP19A1 in undescended testes of dogs with unilateral cryptorchidism.
    Title: Altered expression of CYP17A1 and CYP19A1 in undescended testes of dogs with unilateral cryptorchidism.
  2. overexpression of Arom found in Inflammatory mammary cancer.
    Title: Profile of Steroid Receptors and Increased Aromatase Immunoexpression in Canine Inflammatory Mammary Cancer as a Potential Therapeutic Target.
  3. The presence of aromatase immunoreactivity in neurons, some astrocytes, and endothelial cells suggests estrogen involvement in CNS physiology and function in the dog.
    Title: Cytochrome P450 aromatase expression in canine nervous tissue: an immunohistochemical study.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aromatase
Names
CYPXIX
cytochrome P-450AROM
cytochrome P450 19A1
cytochrome P450, family 17, subfamily A, polypeptide 1
estrogen synthase
estrogen synthetase
NP_001008715.1
XP_038297664.1
XP_038297665.1
XP_038297666.1
XP_038297667.1
XP_038297668.1
XP_038297669.1
XP_038297670.1
XP_038297671.1
XP_038297672.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008715.1 → NP_001008715.1  aromatase

    See identical proteins and their annotated locations for NP_001008715.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ854107
    UniProtKB/Swiss-Prot
    Q5QQX7
    UniProtKB/TrEMBL
    A0A8C0L0F6
    Related
    ENSCAFP00845034575.1, ENSCAFT00845044126.1
    Conserved Domains (1) summary
    pfam00067
    Location:48 → 481
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    17098681..17221672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038441739.1 → XP_038297667.1  aromatase isoform X2

    UniProtKB/TrEMBL
    A0A8C0L0F6, A0A8C0TCX1, A0A8I3PXC9
    Conserved Domains (1) summary
    cd20616
    Location:72 → 485
    CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

  2. XM_038441738.1 → XP_038297666.1  aromatase isoform X2

    UniProtKB/TrEMBL
    A0A8C0L0F6, A0A8C0TCX1, A0A8I3PXC9
    Conserved Domains (1) summary
    cd20616
    Location:72 → 485
    CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

  3. XM_038441737.1 → XP_038297665.1  aromatase isoform X2

    UniProtKB/TrEMBL
    A0A8C0L0F6, A0A8C0TCX1, A0A8I3PXC9
    Conserved Domains (1) summary
    cd20616
    Location:72 → 485
    CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

  4. XM_038441736.1 → XP_038297664.1  aromatase isoform X1

    UniProtKB/TrEMBL
    A0A8C0L0F6
    Conserved Domains (1) summary
    cd20616
    Location:102 → 515
    CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

  5. XM_038441740.1 → XP_038297668.1  aromatase isoform X2

    UniProtKB/TrEMBL
    A0A8C0L0F6, A0A8C0TCX1, A0A8I3PXC9
    Conserved Domains (1) summary
    cd20616
    Location:72 → 485
    CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

  6. XM_038441741.1 → XP_038297669.1  aromatase isoform X3

    UniProtKB/TrEMBL
    A0A8C0L0F6
    Conserved Domains (1) summary
    cd20616
    Location:27 → 440
    CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

  7. XM_038441744.1 → XP_038297672.1  aromatase isoform X5

    UniProtKB/TrEMBL
    A0A8C0L0F6
    Conserved Domains (1) summary
    cd20616
    Location:5 → 418
    CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

  8. XM_038441742.1 → XP_038297670.1  aromatase isoform X4

    UniProtKB/TrEMBL
    A0A8C0L0F6
    Conserved Domains (1) summary
    cd20616
    Location:19 → 432
    CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

  9. XM_038441743.1 → XP_038297671.1  aromatase isoform X4

    UniProtKB/TrEMBL
    A0A8C0L0F6
    Conserved Domains (1) summary
    cd20616
    Location:19 → 432
    CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    17024100..17055822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    17141587..17173348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    17248285..17280035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    16883348..16914898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5QQX7.1 GenPept UniProtKB/Swiss-Prot:Q5QQX7

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