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ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit [ Canis lupus familiaris (dog) ]

Gene ID: 493995, updated on 5-Mar-2024

Summary

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Official Symbol
ERCC2provided by VGNC
Official Full Name
ERCC excision repair 2, TFIIH core complex helicase subunitprovided by VGNC
Primary source
VGNC:VGNC:40442
See related
Ensembl:ENSCAFG00845005380
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ERCC2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
26
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (110706731..110724500)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (109658382..109676142)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (110886053..110903819)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (110382350..110400108)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (110016506..110034248)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 13 like Neighboring gene V-type proton ATPase subunit G 1-like Neighboring gene kinesin light chain 3 Neighboring gene creatine kinase, M-type Neighboring gene microtubule affinity regulating kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nucleotide-excision repair, DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mitotic recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
TFIIH basal transcription factor complex helicase XPD subunit; general transcription and DNA repair factor IIH helicase subunit XPD
Names
excision repair cross-complementing 2
excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)
XP_038282872.1
XP_038282959.1
XP_038283018.1
XP_038323789.1
XP_038323790.1
XP_038323791.1
XP_038323792.1
XP_038384509.1
XP_038384510.1
XP_038384511.1
XP_038384512.1
XP_038448789.1
XP_038448790.1
XP_038448791.1
XP_038448792.1
XP_038512591.1
XP_038512592.1
XP_038512593.1
XP_038512594.1
XP_541562.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    110706731..110724500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038656663.1 → XP_038512591.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDT0, A0A8C0S3N1, A0A8I3MXM9
    Related
    ENSCAFP00845007552.1, ENSCAFT00845009663.1
    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  2. XM_038656664.1 → XP_038512592.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDT0, A0A8C0S3N1, A0A8I3MXM9
    Related
    ENSCAFP00845007514.1, ENSCAFT00845009612.1
    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  3. XM_038656665.1 → XP_038512593.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDT0
    Related
    ENSCAFP00845007479.1, ENSCAFT00845009563.1
    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 684
    rad3; DNA repair helicase (rad3)

  4. XM_038656666.1 → XP_038512594.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X3

    UniProtKB/TrEMBL
    A0A8C0KE82
    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 587
    rad3; DNA repair helicase (rad3)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    110382350..110400108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038467861.1 → XP_038323789.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  2. XM_038467862.1 → XP_038323790.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  3. XM_038467863.1 → XP_038323791.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X2

    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 684
    rad3; DNA repair helicase (rad3)

  4. XM_038467864.1 → XP_038323792.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X3

    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 587
    rad3; DNA repair helicase (rad3)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    110016506..110034248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038592861.1 → XP_038448789.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  2. XM_038592862.1 → XP_038448790.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  3. XM_038592863.1 → XP_038448791.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X2

    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 684
    rad3; DNA repair helicase (rad3)

  4. XM_038592864.1 → XP_038448792.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X3

    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 587
    rad3; DNA repair helicase (rad3)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    110886053..110903819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038528581.1 → XP_038384509.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDT0, A0A8C0S3N1, A0A8I3MXM9
    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  2. XM_038528582.1 → XP_038384510.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDT0, A0A8C0S3N1, A0A8I3MXM9
    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  3. XM_038528583.1 → XP_038384511.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDT0
    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 684
    rad3; DNA repair helicase (rad3)

  4. XM_038528584.1 → XP_038384512.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X3

    UniProtKB/TrEMBL
    A0A8C0KE82
    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 587
    rad3; DNA repair helicase (rad3)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    109658382..109676142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_541562.7 → XP_541562.4  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDT0, A0A8C0S3N1, A0A8I3MXM9
    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  2. XM_038426944.1 → XP_038282872.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDT0, A0A8C0S3N1, A0A8I3MXM9
    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 708
    rad3; DNA repair helicase (rad3)

  3. XM_038427031.1 → XP_038282959.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDT0
    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 684
    rad3; DNA repair helicase (rad3)

  4. XM_038427090.1 → XP_038283018.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X3

    UniProtKB/TrEMBL
    A0A8C0KE82
    Conserved Domains (1) summary
    TIGR00604
    Location:1 → 587
    rad3; DNA repair helicase (rad3)
Nucleotide Protein
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