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ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 [ Danio rerio (zebrafish) ]

Gene ID: 493605, updated on 11-Apr-2024

Summary

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Official Symbol
ndufs1provided by ZNC
Official Full Name
NADH:ubiquinone oxidoreductase core subunit S1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-478
See related
Ensembl:ENSDARG00000028546 AllianceGenome:ZFIN:ZDB-GENE-030131-478
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92209; wu:fb33h05
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to act upstream of or within ATP synthesis coupled electron transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (13206516..13231951)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (12972981..12998416)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DBF-type containing 2 Neighboring gene eukaryotic translation elongation factor 1 beta 2 Neighboring gene INO80 complex subunit Db Neighboring gene potassium inwardly rectifying channel subfamily J member 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Conserved function of caspase-8 in apoptosis during bony fish evolution. Sakata S, et al. Gene, 2007 Jul 1. PMID 17459614, Free PMC Article
  2. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Zhang Q, et al. Nucleic Acids Res, 2021 May 7. PMID 33836087, Free PMC Article
  3. Reprimo tissue-specific expression pattern is conserved between zebrafish and human. Figueroa RJ, et al. PLoS One, 2017. PMID 28562620, Free PMC Article
  4. Differential protein profile in zebrafish (Danio rerio) brain under the joint exposure of methyl parathion and cadmium. Ling XP, et al. Environ Sci Pollut Res Int, 2012 Nov. PMID 22767353
  5. Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity. Hagenaars A, et al. Chemosphere, 2013 May. PMID 23427857

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Names
NADH dehydrogenase (ubiquinone) Fe-S protein 1
NP_001007766.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007765.1 → NP_001007766.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

    See identical proteins and their annotated locations for NP_001007766.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085651
    UniProtKB/TrEMBL
    Q5RKM2
    Related
    ENSDARP00000028571.6, ENSDART00000036927.7
    Conserved Domains (5) summary
    smart00929
    Location:117 → 157
    NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
    PRK09130
    Location:35 → 727
    PRK09130; NADH dehydrogenase subunit G; Validated
    cd02773
    Location:253 → 634
    MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
    pfam09326
    Location:682 → 714
    NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
    pfam13510
    Location:33 → 111
    Fer2_4; 2Fe-2S iron-sulfur cluster binding domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    13206516..13231951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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