ASIP agouti signaling protein [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ASIPprovided by VGNC
Official Full Name: agouti signaling proteinprovided by VGNC
Primary source: VGNC:VGNC:38182
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: agouti
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	24	NC_051828.1 (24041356..24084629)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	24	NC_006606.4 (22999470..23041722)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	24	NC_049245.1 (23865404..23906575)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	24	NC_049284.1 (23334340..23373386)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	24	NC_049765.1 (23428191..23467532)

Chromosome 24 - NC_051828.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study suggest that differential expression of ASIP determine pigment-type switching in a MC1R and K allele-dependent manner in dogs.
Title: Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs.
A SINE insertion in intron 1 of ASIP causes the black-and-tan and saddle tan phenotypes in domestic dogs.
Title: A SINE insertion causes the black-and-tan and saddle tan phenotypes in domestic dogs.
2 key mutations in the MC1R gene and the CBD103 gene are associated with the phenotypic discriminations among brindle, red/sesame, and white coats.
Title: Mutations in the melanocortin 1 receptor, β-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs.
Coyote-dog hybrids were heterozygous for 2 mutations causing fawn coat color in dogs.
Title: Agouti sequence polymorphisms in coyotes, wolves and dogs suggest hybridization.
Mc1r is epistatic to variation at Agouti or K and the epistatic relationship between Agouti and K depends on the alleles being tested.
Title: Linkage and segregation analysis of black and brindle coat color in domestic dogs.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables melanocortin receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in melanosome organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of melanin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: agouti-signaling protein

Names: ASP; agouti signal peptide; agouti signaling protein, nonagouti homolog; agouti switch protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007263.1 → NP_001007264.1 agouti-signaling protein precursor

See identical proteins and their annotated locations for NP_001007264.1

Status: PROVISIONAL

Source sequence(s)

AY714374

UniProtKB/Swiss-Prot

Q5UK76

Conserved Domains (1) summary

smart00792
Location:16 → 127

Agouti; Agouti protein

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051828.1 Reference ROS_Cfam_1.0

Range

24041356..24084629

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038432838.1 → XP_038288766.1 agouti-signaling protein isoform X1

UniProtKB/Swiss-Prot

Q5UK76

Conserved Domains (1) summary

smart00792
Location:16 → 127

Agouti; Agouti protein
XM_038432839.1 → XP_038288767.1 agouti-signaling protein isoform X1

UniProtKB/Swiss-Prot

Q5UK76

Conserved Domains (1) summary

smart00792
Location:16 → 127

Agouti; Agouti protein