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MCF2 MCF.2 cell line derived transforming sequence [ Canis lupus familiaris (dog) ]

Gene ID: 492176, updated on 5-Mar-2024

Summary

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Official Symbol
MCF2provided by VGNC
Official Full Name
MCF.2 cell line derived transforming sequenceprovided by VGNC
Primary source
VGNC:VGNC:49923
See related
Ensembl:ENSCAFG00845029804
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (111530138..111601036, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (95370950..95454589, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (110528154..110611768, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (108664168..108747786, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (110848683..110932293, complement)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene ferritin heavy chain-like Neighboring gene U4 spliceosomal RNA Neighboring gene coagulation factor IX Neighboring gene ATPase phospholipid transporting 11C Neighboring gene uncharacterized LOC102156336 Neighboring gene microRNA mir-505 Neighboring gene chromosome X CXorf66 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene DBL

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    111530138..111601036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038450999.1 → XP_038306927.1  proto-oncogene DBL isoform X6

    UniProtKB/TrEMBL
    A0A8C0S8A6, A0A8I3Q280, A0A8I3Q4V8
    Related
    ENSCAFP00845041544.1, ENSCAFT00845052909.1
    Conserved Domains (4) summary
    cd11857
    Location:878 → 932
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:457 → 634
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:186 → 377
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:641 → 772
    PH-like; Pleckstrin homology-like domain

  2. XM_038450997.1 → XP_038306925.1  proto-oncogene DBL isoform X4

    UniProtKB/TrEMBL
    A0A8I3Q4V8
    Conserved Domains (4) summary
    cd11857
    Location:894 → 948
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:473 → 650
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:186 → 377
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:657 → 788
    PH-like; Pleckstrin homology-like domain

  3. XM_038450996.1 → XP_038306924.1  proto-oncogene DBL isoform X3

    UniProtKB/TrEMBL
    A0A8C0SA04, A0A8I3Q822, A0A8I3Q8N1, A0A8P0SWK3
    Related
    ENSCAFP00845041478.1, ENSCAFT00845052833.1
    Conserved Domains (5) summary
    cd11857
    Location:917 → 971
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:496 → 673
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:225 → 416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:20 → 85
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl17171
    Location:680 → 811
    PH-like; Pleckstrin homology-like domain

  4. XM_038450994.1 → XP_038306922.1  proto-oncogene DBL isoform X1

    UniProtKB/TrEMBL
    A0A8C0SA04, A0A8C0YV82, A0A8I3Q822
    Conserved Domains (5) summary
    cd11857
    Location:933 → 987
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:512 → 689
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:225 → 416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:20 → 85
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl17171
    Location:696 → 827
    PH-like; Pleckstrin homology-like domain

  5. XM_038450995.1 → XP_038306923.1  proto-oncogene DBL isoform X2

    UniProtKB/TrEMBL
    A0A8C0SA04, A0A8I3Q822
    Related
    ENSCAFP00845041663.1, ENSCAFT00845053062.1
    Conserved Domains (5) summary
    cd11857
    Location:933 → 987
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:512 → 689
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:225 → 416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:20 → 85
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl17171
    Location:696 → 827
    PH-like; Pleckstrin homology-like domain

  6. XM_038450998.1 → XP_038306926.1  proto-oncogene DBL isoform X5

    UniProtKB/TrEMBL
    A0A8C0SA04, A0A8I3Q822
    Related
    ENSCAFP00845041677.1, ENSCAFT00845053080.1
    Conserved Domains (5) summary
    cd00160
    Location:512 → 689
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:225 → 416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:20 → 85
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl17036
    Location:933 → 968
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:696 → 827
    PH-like; Pleckstrin homology-like domain

  7. XM_038451000.1 → XP_038306928.1  proto-oncogene DBL isoform X7

    UniProtKB/TrEMBL
    A0A8C0SA93, A0A8I3QLI5
    Related
    ENSCAFP00845041721.1, ENSCAFT00845053130.1
    Conserved Domains (4) summary
    cd00160
    Location:512 → 689
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:225 → 416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:20 → 85
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl17171
    Location:696 → 827
    PH-like; Pleckstrin homology-like domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    108664168..108747786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038524469.1 → XP_038380397.1  proto-oncogene DBL isoform X10

  2. XM_038524467.1 → XP_038380395.1  proto-oncogene DBL isoform X8

  3. XM_038524470.1 → XP_038380398.1  proto-oncogene DBL isoform X1

    Conserved Domains (5) summary
    cd11857
    Location:933 → 987
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:512 → 689
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:225 → 416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:20 → 85
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl17171
    Location:696 → 827
    PH-like; Pleckstrin homology-like domain

  4. XM_038524468.1 → XP_038380396.1  proto-oncogene DBL isoform X9

    Conserved Domains (5) summary
    cd11857
    Location:993 → 1047
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:5 → 145
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:572 → 749
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:285 → 476
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:756 → 887
    PH-like; Pleckstrin homology-like domain

  5. XM_038524471.1 → XP_038380399.1  proto-oncogene DBL isoform X11

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    110848683..110932293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038652961.1 → XP_038508889.1  proto-oncogene DBL isoform X14

  2. XM_038652959.1 → XP_038508887.1  proto-oncogene DBL isoform X12

  3. XM_038652962.1 → XP_038508890.1  proto-oncogene DBL isoform X1

    Conserved Domains (5) summary
    cd11857
    Location:933 → 987
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:512 → 689
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:225 → 416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:20 → 85
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl17171
    Location:696 → 827
    PH-like; Pleckstrin homology-like domain

  4. XM_038652960.1 → XP_038508888.1  proto-oncogene DBL isoform X13

    Conserved Domains (5) summary
    cd11857
    Location:993 → 1047
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:5 → 145
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:572 → 749
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:285 → 476
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:756 → 887
    PH-like; Pleckstrin homology-like domain

  5. XM_038652963.1 → XP_038508891.1  proto-oncogene DBL isoform X15

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    110528154..110611768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038588441.1 → XP_038444369.1  proto-oncogene DBL isoform X18

    UniProtKB/TrEMBL
    A0A8P0NZS3, A0A8P0T265

  2. XM_038588439.1 → XP_038444367.1  proto-oncogene DBL isoform X16

    UniProtKB/TrEMBL
    A0A8P0T265

  3. XM_038588442.1 → XP_038444370.1  proto-oncogene DBL isoform X1

    UniProtKB/TrEMBL
    A0A8C0SA04, A0A8C0YV82, A0A8I3Q822
    Conserved Domains (5) summary
    cd11857
    Location:933 → 987
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:512 → 689
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:225 → 416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:20 → 85
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl17171
    Location:696 → 827
    PH-like; Pleckstrin homology-like domain

  4. XM_038588440.1 → XP_038444368.1  proto-oncogene DBL isoform X17

    UniProtKB/TrEMBL
    A0A8P0NZP3
    Conserved Domains (5) summary
    cd11857
    Location:993 → 1047
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:5 → 145
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:572 → 749
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:285 → 476
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:756 → 887
    PH-like; Pleckstrin homology-like domain

  5. XM_038588443.1 → XP_038444371.1  proto-oncogene DBL isoform X19

    UniProtKB/TrEMBL
    A0A8C0SAQ4, A0A8P0NX09

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    95370950..95454589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022415983.2 → XP_022271691.1  proto-oncogene DBL isoform X22

    UniProtKB/TrEMBL
    A0A8P0NZS3, A0A8P0T265
    Conserved Domains (5) summary
    cd11857
    Location:977 → 1031
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:5 → 145
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:556 → 733
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:285 → 476
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:740 → 871
    PH-like; Pleckstrin homology-like domain

  2. XM_022415982.2 → XP_022271690.1  proto-oncogene DBL isoform X20

    UniProtKB/TrEMBL
    A0A8P0T265
    Conserved Domains (5) summary
    cd11857
    Location:993 → 1047
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:5 → 145
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:572 → 749
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:285 → 476
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:756 → 887
    PH-like; Pleckstrin homology-like domain

  3. XM_022415984.2 → XP_022271692.1  proto-oncogene DBL isoform X1

    UniProtKB/TrEMBL
    A0A8C0SA04, A0A8C0YV82, A0A8I3Q822
    Conserved Domains (5) summary
    cd11857
    Location:933 → 987
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:512 → 689
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:225 → 416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:20 → 85
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl17171
    Location:696 → 827
    PH-like; Pleckstrin homology-like domain

  4. XM_038464876.1 → XP_038320804.1  proto-oncogene DBL isoform X21

    UniProtKB/TrEMBL
    A0A8P0NZP3
    Conserved Domains (5) summary
    cd11857
    Location:993 → 1047
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:5 → 145
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:572 → 749
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:285 → 476
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:756 → 887
    PH-like; Pleckstrin homology-like domain

  5. XM_022415985.2 → XP_022271693.1  proto-oncogene DBL isoform X23

    UniProtKB/TrEMBL
    A0A8C0SAQ4, A0A8P0NX09
    Conserved Domains (4) summary
    smart00516
    Location:5 → 145
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:572 → 749
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl02488
    Location:285 → 476
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:756 → 887
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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