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PAK3 p21 (RAC1) activated kinase 3 [ Canis lupus familiaris (dog) ]

Gene ID: 492067, updated on 5-Mar-2024

Summary

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Official Symbol
PAK3provided by VGNC
Official Full Name
p21 (RAC1) activated kinase 3provided by VGNC
Primary source
VGNC:VGNC:53550
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (85871706..85997455)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (70164167..70430936)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (84724769..84986483)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (83206488..83474638)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (84896488..85157976)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene cell division control protein 42 homolog Neighboring gene uncharacterized LOC119868500 Neighboring gene U6 spliceosomal RNA Neighboring gene calpain 6 Neighboring gene doublecortin Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 3
Names
p21 (CDKN1A)-activated kinase 3
XP_003435695.2
XP_005641738.1
XP_005641740.1
XP_005641742.1
XP_005641747.1
XP_005641750.1
XP_005641751.1
XP_005641752.1
XP_005641753.1
XP_038305129.1
XP_038320209.1
XP_038320210.1
XP_038380031.1
XP_038380032.1
XP_038380033.1
XP_038380034.1
XP_038380035.1
XP_038380036.1
XP_038380037.1
XP_038380038.1
XP_038380040.1
XP_038380041.1
XP_038380042.1
XP_038380043.1
XP_038444007.1
XP_038444008.1
XP_038444009.1
XP_038444010.1
XP_038444011.1
XP_038444012.1
XP_038444013.1
XP_038444015.1
XP_038444016.1
XP_038444017.1
XP_038444018.1
XP_038444019.1
XP_038508524.1
XP_038508525.1
XP_038508526.1
XP_038508527.1
XP_038508528.1
XP_038508529.1
XP_038508530.1
XP_038508531.1
XP_038508532.1
XP_038508533.1
XP_038508534.1
XP_038508535.1
XP_549187.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    85871706..85997455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038449201.1 → XP_038305129.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RQ24
    Conserved Domains (2) summary
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain
    cl21453
    Location:212 → 499
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    83206488..83474638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038524106.1 → XP_038380034.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  2. XM_038524108.1 → XP_038380036.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  3. XM_038524109.1 → XP_038380037.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  4. XM_038524105.1 → XP_038380033.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  5. XM_038524107.1 → XP_038380035.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  6. XM_038524103.1 → XP_038380031.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  7. XM_038524104.1 → XP_038380032.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  8. XM_038524112.1 → XP_038380040.1  serine/threonine-protein kinase PAK 3 isoform X4

  9. XM_038524110.1 → XP_038380038.1  serine/threonine-protein kinase PAK 3 isoform X3

    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  10. XM_038524113.1 → XP_038380041.1  serine/threonine-protein kinase PAK 3 isoform X5

  11. XM_038524114.1 → XP_038380042.1  serine/threonine-protein kinase PAK 3 isoform X6

    Conserved Domains (2) summary
    cd06647
    Location:260 → 515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  12. XM_038524115.1 → XP_038380043.1  serine/threonine-protein kinase PAK 3 isoform X7

    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    84896488..85157976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038652599.1 → XP_038508527.1  serine/threonine-protein kinase PAK 3 isoform X8

  2. XM_038652601.1 → XP_038508529.1  serine/threonine-protein kinase PAK 3 isoform X8

  3. XM_038652602.1 → XP_038508530.1  serine/threonine-protein kinase PAK 3 isoform X8

  4. XM_038652598.1 → XP_038508526.1  serine/threonine-protein kinase PAK 3 isoform X8

  5. XM_038652600.1 → XP_038508528.1  serine/threonine-protein kinase PAK 3 isoform X8

  6. XM_038652596.1 → XP_038508524.1  serine/threonine-protein kinase PAK 3 isoform X8

  7. XM_038652597.1 → XP_038508525.1  serine/threonine-protein kinase PAK 3 isoform X8

  8. XM_038652604.1 → XP_038508532.1  serine/threonine-protein kinase PAK 3 isoform X10

  9. XM_038652603.1 → XP_038508531.1  serine/threonine-protein kinase PAK 3 isoform X9

  10. XM_038652605.1 → XP_038508533.1  serine/threonine-protein kinase PAK 3 isoform X11

  11. XM_038652606.1 → XP_038508534.1  serine/threonine-protein kinase PAK 3 isoform X12

    Conserved Domains (2) summary
    cd06647
    Location:260 → 515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  12. XM_038652607.1 → XP_038508535.1  serine/threonine-protein kinase PAK 3 isoform X13

    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    84724769..84986483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038588082.1 → XP_038444010.1  serine/threonine-protein kinase PAK 3 isoform X14

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  2. XM_038588084.1 → XP_038444012.1  serine/threonine-protein kinase PAK 3 isoform X14

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  3. XM_038588085.1 → XP_038444013.1  serine/threonine-protein kinase PAK 3 isoform X14

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  4. XM_038588081.1 → XP_038444009.1  serine/threonine-protein kinase PAK 3 isoform X14

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  5. XM_038588083.1 → XP_038444011.1  serine/threonine-protein kinase PAK 3 isoform X14

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  6. XM_038588079.1 → XP_038444007.1  serine/threonine-protein kinase PAK 3 isoform X14

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  7. XM_038588080.1 → XP_038444008.1  serine/threonine-protein kinase PAK 3 isoform X14

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  8. XM_038588088.1 → XP_038444016.1  serine/threonine-protein kinase PAK 3 isoform X16

    UniProtKB/TrEMBL
    A0A8C0JX80, A0A8P0SM06

  9. XM_038588087.1 → XP_038444015.1  serine/threonine-protein kinase PAK 3 isoform X15

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SLD6
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  10. XM_038588089.1 → XP_038444017.1  serine/threonine-protein kinase PAK 3 isoform X17

    UniProtKB/TrEMBL
    A0A8C0JX80, A0A8C0SLS9

  11. XM_038588090.1 → XP_038444018.1  serine/threonine-protein kinase PAK 3 isoform X18

    UniProtKB/TrEMBL
    A0A8C0JY74
    Conserved Domains (2) summary
    cd06647
    Location:260 → 515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  12. XM_038588091.1 → XP_038444019.1  serine/threonine-protein kinase PAK 3 isoform X19

    UniProtKB/TrEMBL
    A0A8C0JYT3, A0A8C0YYN2, A0A8P0NUY8
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    70164167..70430936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038464281.1 → XP_038320209.1  serine/threonine-protein kinase PAK 3 isoform X20

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  2. XM_005641690.4 → XP_005641747.1  serine/threonine-protein kinase PAK 3 isoform X20

    See identical proteins and their annotated locations for XP_005641747.1

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  3. XM_005641683.4 → XP_005641740.1  serine/threonine-protein kinase PAK 3 isoform X20

    See identical proteins and their annotated locations for XP_005641740.1

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  4. XM_038464282.1 → XP_038320210.1  serine/threonine-protein kinase PAK 3 isoform X20

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  5. XM_003435647.5 → XP_003435695.2  serine/threonine-protein kinase PAK 3 isoform X20

    See identical proteins and their annotated locations for XP_003435695.2

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  6. XM_005641681.4 → XP_005641738.1  serine/threonine-protein kinase PAK 3 isoform X20

    See identical proteins and their annotated locations for XP_005641738.1

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  7. XM_005641685.4 → XP_005641742.1  serine/threonine-protein kinase PAK 3 isoform X20

    See identical proteins and their annotated locations for XP_005641742.1

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SQ25, A0A8P0T9M7
    Conserved Domains (2) summary
    cd06647
    Location:296 → 551
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  8. XM_005641694.4 → XP_005641751.1  serine/threonine-protein kinase PAK 3 isoform X22

    UniProtKB/TrEMBL
    A0A8C0JX80, A0A8P0SM06
    Conserved Domains (2) summary
    cd06647
    Location:275 → 530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  9. XM_005641693.4 → XP_005641750.1  serine/threonine-protein kinase PAK 3 isoform X21

    UniProtKB/TrEMBL
    A0A8C0JVP0, A0A8C0SLD6
    Conserved Domains (2) summary
    cd06656
    Location:284 → 580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 162
    PBD; P21-Rho-binding domain

  10. XM_005641695.4 → XP_005641752.1  serine/threonine-protein kinase PAK 3 isoform X23

    UniProtKB/TrEMBL
    A0A8C0JX80, A0A8C0SLS9
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  11. XM_005641696.4 → XP_005641753.1  serine/threonine-protein kinase PAK 3 isoform X24

    UniProtKB/TrEMBL
    A0A8C0JY74
    Conserved Domains (2) summary
    cd06647
    Location:260 → 515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  12. XM_549187.7 → XP_549187.2  serine/threonine-protein kinase PAK 3 isoform X25

    UniProtKB/TrEMBL
    A0A8C0JYT3, A0A8C0YYN2, A0A8P0NUY8
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain
Nucleotide Protein
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