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ARAF A-Raf proto-oncogene, serine/threonine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 491857, updated on 5-Mar-2024

Summary

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Official Symbol
ARAFprovided by VGNC
Official Full Name
A-Raf proto-oncogene, serine/threonine kinaseprovided by VGNC
Primary source
VGNC:VGNC:38024
See related
Ensembl:ENSCAFG00845030502
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ARAF in Genome Data Viewer
Location:
chromosome: X
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (41314276..41325765)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (15555116..15566605)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (41382798..41394286)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (41301898..41313372)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (41290159..41301648)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene methylosome subunit pICln-like Neighboring gene zinc finger protein 157 Neighboring gene protein archease-like Neighboring gene zinc finger protein 41 Neighboring gene synapsin I Neighboring gene TIMP metallopeptidase inhibitor 1 Neighboring gene complement factor properdin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase A-Raf
Names
v-raf murine sarcoma 3611 viral oncogene homolog
XP_013967075.2
XP_038305831.1
XP_038379274.1
XP_038443242.1
XP_038507753.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    41314276..41325765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038449903.1 → XP_038305831.1  serine/threonine-protein kinase A-Raf

    UniProtKB/TrEMBL
    A0A8C0LB93, A0A8C0T3V7, A0A8I3S7N0, A0A8P0PLJ1
    Related
    ENSCAFP00845042527.1, ENSCAFT00845054125.1
    Conserved Domains (3) summary
    cd17133
    Location:19 → 91
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cd20870
    Location:96 → 147
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    cl21453
    Location:309 → 573
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    41301898..41313372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038523346.1 → XP_038379274.1  serine/threonine-protein kinase A-Raf

    Conserved Domains (3) summary
    cd17133
    Location:19 → 91
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cd20870
    Location:96 → 147
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    cl21453
    Location:309 → 573
    PKc_like; Protein Kinases, catalytic domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    41290159..41301648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038651825.1 → XP_038507753.1  serine/threonine-protein kinase A-Raf

    Conserved Domains (3) summary
    cd17133
    Location:19 → 91
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cd20870
    Location:96 → 147
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    cl21453
    Location:309 → 573
    PKc_like; Protein Kinases, catalytic domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    41382798..41394286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038587314.1 → XP_038443242.1  serine/threonine-protein kinase A-Raf

    UniProtKB/TrEMBL
    A0A8C0LB93, A0A8C0T3V7, A0A8I3S7N0, A0A8P0PLJ1
    Conserved Domains (3) summary
    cd17133
    Location:19 → 91
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cd20870
    Location:96 → 147
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    cl21453
    Location:309 → 573
    PKc_like; Protein Kinases, catalytic domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    15555116..15566605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014111600.3 → XP_013967075.2  serine/threonine-protein kinase A-Raf

    UniProtKB/TrEMBL
    A0A8C0LB93, A0A8C0T3V7, A0A8I3S7N0, A0A8P0PLJ1
    Conserved Domains (3) summary
    cd17133
    Location:19 → 91
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cd20870
    Location:96 → 147
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    cl21453
    Location:309 → 573
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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